Molecule Details
| InChIKey | RYYNGWLOYLRZLK-RBUKOAKNSA-N |
|---|---|
| Compound Name | Pf-03814735 |
| Canonical SMILES | CC(=O)NCC(=O)N1[C@@H]2CC[C@H]1c1ccc(Nc3ncc(C(F)(F)F)c(NC4CCC4)n3)cc12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 45 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.96 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB13059 |
|---|---|
| Drug Name | PF-03814735 |
| CAS Number | 942487-16-3 |
| Groups | investigational |
| ATC Codes | nan |
| Description | PF-03814735 has been used in trials studying the treatment of Solid Tumors. |
Categories: Heterocyclic Compounds, Fused-Ring Protein Kinase Inhibitors
Cross-references: ChemSpider: 28637806 PDB: 34W PubChem:51346455 PubChem:347829187 ZINC: ZINC000043196229
Target Activities (45)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O14965 | AURKA | Homo sapiens | Human | PF00069 | 9.1 | IC50 | ChEMBL;BindingDB |
| Q13873 | BMPR2 | Homo sapiens | Human | PF01064 PF00069 | 8.1 | Kd | ChEMBL |
| Q2M2I8 | AAK1 | Homo sapiens | Human | PF00069 | 8.1 | Kd | ChEMBL |
| Q96L34 | MARK4 | Homo sapiens | Human | PF02149 PF00069 PF00627 | 8.1 | Kd | ChEMBL |
| Q6ZSR9 | Homo sapiens | Human | PF15282 | 8.0 | Kd | ChEMBL | |
| Q96GD4 | AURKB | Homo sapiens | Human | PF00069 | 8.0 | IC50 | ChEMBL;BindingDB |
| Q9H0K1 | SIK2 | Homo sapiens | Human | PF00069 PF23312 | 8.0 | Kd | ChEMBL |
| Q9NSY1 | BMP2K | Homo sapiens | Human | PF15282 PF00069 | 7.8 | Kd | ChEMBL |
| P07949 | RET | Homo sapiens | Human | PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 | 7.8 | Kd | ChEMBL |
| Q6PHR2 | ULK3 | Homo sapiens | Human | PF04212 PF00069 | 7.7 | Kd | ChEMBL |
| Q9Y6E0 | STK24 | Homo sapiens | Human | PF20929 PF00069 | 7.7 | Kd | ChEMBL |
| Q9H093 | NUAK2 | Homo sapiens | Human | PF00069 | 7.6 | Kd | ChEMBL |
| O75385 | ULK1 | Homo sapiens | Human | PF12063 PF21127 PF00069 | 7.5 | Kd | ChEMBL |
| P36888 | FLT3 | Homo sapiens | Human | PF00047 PF07714 | 7.4 | Kd | ChEMBL |
| Q16584 | MAP3K11 | Homo sapiens | Human | PF07714 PF14604 | 7.3 | Kd | ChEMBL |
| Q05397 | PTK2 | Homo sapiens | Human | PF21477 PF00373 PF18038 PF03623 PF07714 | 7.2 | Kd | ChEMBL |
| Q9UHD2 | TBK1 | Homo sapiens | Human | PF00069 PF18394 PF18396 | 7.1 | Kd | ChEMBL |
| P30291 | WEE1 | Homo sapiens | Human | PF00069 | 7.1 | Kd | ChEMBL |
| P16591 | FER | Homo sapiens | Human | PF00611 PF07714 PF00017 | 7.0 | Kd | ChEMBL |
| Q32MK0 | MYLK3 | Homo sapiens | Human | PF00069 | 7.0 | Kd | ChEMBL |
| P0C1S8 | WEE2 | Homo sapiens | Human | PF00069 | 6.9 | Kd | ChEMBL |
| O75676 | RPS6KA4 | Homo sapiens | Human | PF00069 PF00433 | 6.8 | Kd | ChEMBL |
| Q9Y2U5 | MAP3K2 | Homo sapiens | Human | PF00564 PF00069 | 6.8 | Kd | ChEMBL |
| Q99759 | MAP3K3 | Homo sapiens | Human | PF00564 PF00069 | 6.6 | Kd | ChEMBL |
| P04629 | NTRK1 | Homo sapiens | Human | PF13855 PF16920 PF07714 PF18613 | 6.6 | Kd | ChEMBL |
| Q14289 | PTK2B | Homo sapiens | Human | PF21477 PF00373 PF18038 PF03623 PF07714 | 6.6 | Kd | ChEMBL |
| O00444 | PLK4 | Homo sapiens | Human | PF00069 PF18190 PF18409 | 6.6 | Kd | ChEMBL |
| Q9UK32 | RPS6KA6 | Homo sapiens | Human | PF00069 PF00433 | 6.5 | Kd | ChEMBL |
| O94804 | STK10 | Homo sapiens | Human | PF00069 PF12474 | 6.5 | Kd | ChEMBL |
| Q13131 | PRKAA1 | Homo sapiens | Human | PF16579 PF21147 PF00069 | 6.5 | Kd | ChEMBL |
| P27448 | MARK3 | Homo sapiens | Human | PF02149 PF00069 PF00627 | 6.4 | Kd | ChEMBL |
| Q13470 | TNK1 | Homo sapiens | Human | PF07714 PF22931 | 6.4 | Kd | ChEMBL |
| O95835 | LATS1 | Homo sapiens | Human | PF00069 PF00433 PF00627 | 6.4 | Kd | ChEMBL |
| O14757 | CHEK1 | Homo sapiens | Human | PF00069 | 6.4 | Kd | ChEMBL |
| Q00535 | CDK5 | Homo sapiens | Human | PF00069 | 6.3 | Kd | ChEMBL |
| Q7KZI7 | MARK2 | Homo sapiens | Human | PF02149 PF00069 PF00627 | 6.2 | Kd | ChEMBL |
| P43405 | SYK | Homo sapiens | Human | PF07714 PF00017 | 6.2 | Kd | ChEMBL |
| Q9H2G2 | SLK | Homo sapiens | Human | PF00069 PF12474 | 6.2 | Kd | ChEMBL |
| Q9UKE5 | TNIK | Homo sapiens | Human | PF00780 PF00069 | 6.1 | Kd | ChEMBL |
| Q8IVH8 | MAP4K3 | Homo sapiens | Human | PF00780 PF00069 | 6.1 | Kd | ChEMBL |
| Q14164 | IKBKE | Homo sapiens | Human | PF00069 PF18394 PF18396 | 6.1 | Kd | ChEMBL |
| O94806 | PRKD3 | Homo sapiens | Human | PF00130 PF00169 PF00069 PF25525 | 6.1 | Kd | ChEMBL |
| Q13043 | STK4 | Homo sapiens | Human | PF11629 PF00069 | 6.1 | Kd | ChEMBL |
| Q9Y4K4 | MAP4K5 | Homo sapiens | Human | PF00780 PF00069 | 6.0 | Kd | ChEMBL |
| Q9BZL6 | PRKD2 | Homo sapiens | Human | PF00130 PF00169 PF00069 PF25525 | 6.0 | Kd | ChEMBL |