InChIKey	RYIDHLJADOKWFM-MAODMQOUSA-N
Compound Name	Samidorphan
Canonical SMILES	NC(=O)c1ccc2c(c1O)[C@]13CCN(CC4CC4)[C@H](C2)[C@]1(O)CCC(=O)C3
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Homologous
Avg pChEMBL	9.5
Source	ChEMBL;BindingDB

DrugBank ID	DB12543
Drug Name	Samidorphan
CAS Number	852626-89-2
Groups	approved investigational
ATC Codes	N05AH53
Description	[Olanzapine] is an effective atypical antipsychotic that, like other antipsychotics, is associated with weight gain, metabolic dysfunction, and increased risk of type II diabetes.[A235638, A235643] Samidorphan is a novel opioid antagonist structurally related to [naltrexone], with a higher affinity ...

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Categories: Alkaloids Antipsychotic Agents Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 Substrates Diazepines, Oxazepines, Thiazepines and Oxepines Heterocyclic Compounds, Fused-Ring Morphinans Nervous System Opiate Alkaloids Opioid Antagonists Peripheral Nervous System Agents Phenanthrenes Psycholeptics Sensory System Agents

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Cross-references: BindingDB: 50165049 CHEMBL426084 ChemSpider: 23259667 PubChem:11667832 PubChem:347828769 RxCUI: 2559612 Wikipedia: Samidorphan ZINC: ZINC000028478244