Molecule Details
| InChIKey | RYAYYVTWKAOAJF-QISPRATLSA-N |
|---|---|
| Canonical SMILES | CC1(C)CCC2(CC1)N[C@@H](C(=O)N[C@@H]1CC[C@@H](C(N)=O)OC1)[C@H](c1ccnc(Cl)c1F)[C@]21C(=O)Nc2cc(Cl)ccc21 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 8.25 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB15257 |
|---|---|
| Drug Name | Milademetan |
| CAS Number | 1398568-47-2 |
| Groups | investigational |
| ATC Codes | nan |
| Description | Milademetan is under investigation in clinical trial NCT02319369 (Safety, Tolerability and Pharmacokinetics of Milademetan Alone and With 5-Azacitidine (AZA) in Acute Myelogenous Leukemia (AML) or High-Risk Myelodysplastic Syndrome (MDS)). |
Categories: Heterocyclic Compounds, Fused-Ring
Cross-references: ChemSpider: 58828164
Target Activities (2)
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P00451 | F8 | Coagulation factor VIII | other/unknown | targets |