Molecule Details
InChIKeyRXPZOSHFGJWSLQ-UHFFFAOYSA-N
Compound NameTilfrinib
Canonical SMILESOc1cccc(Nc2ccnc3[nH]c4ccccc4c23)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)6
Pfam Stratification Cross-Family
Avg pChEMBL6.93
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (6)
Target Gene Organism Category Pfam pChEMBL Type Source
Q13882 PTK6 Homo sapiens Human PF07714 PF00017 PF00018 8.5 IC50 ChEMBL;BindingDB
Q04771 ACVR1 Homo sapiens Human PF01064 PF07714 PF08515 6.7 IC50 ChEMBL
Q9UM73 ALK Homo sapiens Human PF12810 PF00629 PF07714 6.7 IC50 ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.6 IC50 ChEMBL
Q9UQB9 AURKC Homo sapiens Human PF00069 6.6 IC50 ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.6 IC50 ChEMBL