Molecule Details
| InChIKey | RXCVUHMIWHRLDF-HXUWFJFHSA-N |
|---|---|
| Canonical SMILES | COc1cc(C)[nH]c(=O)c1CN1CCc2c(Cl)cc([C@H](OC)C3COC3)c(Cl)c2C1=O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.81 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB14799 |
|---|---|
| Drug Name | PF-06821497 |
| CAS Number | 1844849-10-0 |
| Groups | investigational |
| ATC Codes | nan |
| Description | PF-06821497 is under investigation in clinical trial NCT03460977 (PF-06821497 Treatment Of Relapsed/Refractory SCLC, Castration Resistant Prostate Cancer, and Follicular Lymphoma). |
Cross-references: CHEMBL4080228 ChemSpider: 65321668 PDB: CJD
Target Activities (2)
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q15910 | EZH2 | Histone-lysine N-methyltransferase EZH2 | inhibitor | targets |