Molecule Details
| InChIKey | RWVIMCIPOAXUDG-UHFFFAOYSA-N |
|---|---|
| Compound Name | Dnqx |
| Canonical SMILES | O=[N+]([O-])c1cc2nc(O)c(O)nc2cc1[N+](=O)[O-] |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 11 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.25 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB03759 |
|---|---|
| Drug Name | FG-9041 |
| CAS Number | 2379-57-9 |
| Groups | experimental |
| ATC Codes | nan |
| Description | nan |
Categories: Excitatory Amino Acid Agents Excitatory Amino Acid Antagonists Heterocyclic Compounds, Fused-Ring Neurotransmitter Agents
Cross-references: BindingDB: 50002698 ChEBI: 93492 CHEMBL155265 ChemSpider: 3123097 PDB: DNQ PubChem:3899541 PubChem:46505600 ZINC: ZINC000018118278
Target Activities (11)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P42261 | GRIA1 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.5 | IC50 | ChEMBL |
| P42262 | GRIA2 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.5 | IC50 | ChEMBL |
| P42263 | GRIA3 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.5 | IC50 | ChEMBL |
| P48058 | GRIA4 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.5 | IC50 | ChEMBL |
| O15399 | GRIN2D | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.1 | IC50 | ChEMBL |
| O60391 | GRIN3B | Homo sapiens | Human | PF00060 PF10613 | 6.1 | IC50 | ChEMBL |
| Q05586 | GRIN1 | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.1 | IC50 | ChEMBL |
| Q12879 | GRIN2A | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 6.1 | IC50 | ChEMBL |
| Q13224 | GRIN2B | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 6.1 | IC50 | ChEMBL |
| Q14957 | GRIN2C | Homo sapiens | Human | PF01094 PF00060 PF10613 PF10565 | 6.1 | IC50 | ChEMBL |
| Q8TCU5 | GRIN3A | Homo sapiens | Human | PF01094 PF00060 PF10613 | 6.1 | IC50 | ChEMBL |
DrugBank Target Actions (6)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P42262 | GRIA2 | Glutamate receptor 2 | binder | targets |
| P39086 | GRIK1 | Glutamate receptor ionotropic, kainate 1 | inhibitor | targets |
| P42261 | GRIA1 | Glutamate receptor 1 | inhibitor | targets |
| Q05586 | GRIN1 | Glutamate receptor ionotropic, NMDA 1 | inhibitor | targets |
| Q12879 | GRIN2A | Glutamate receptor ionotropic, NMDA 2A | inhibitor | targets |
| Q13224 | GRIN2B | Glutamate receptor ionotropic, NMDA 2B | inhibitor | targets |