Molecule Details
| InChIKey | RWEVIPRMPFNTLO-UHFFFAOYSA-N |
|---|---|
| Canonical SMILES | Cc1cc(C(=O)NOCCO)c(Nc2ccc(I)cc2F)n(C)c1=O |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 8.07 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB06061 |
|---|---|
| Drug Name | AZD-8330 |
| CAS Number | 869357-68-6 |
| Groups | investigational |
| ATC Codes | nan |
| Description | AZD-8330 is a potent, selective, orally active MEK inhibitor that blocks signal transduction pathways implicated in cancer cell proliferation and survival. AZD-8330 has shown tumor suppressive activity in multiple preclinical models of human cancer including melanoma, pancreatic, colon, lung, and br... |
Categories: Protein Kinase Inhibitors Pyridines
Cross-references: ChEBI: 91424 CHEMBL3182621 ChemSpider: 17599746 PubChem:16666708 PubChem:347827753 ZINC: ZINC000043152942
Target Activities (2)
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q13233 | MAP3K1 | Mitogen-activated protein kinase kinase kinase 1 | binder | targets |