Molecule Details
InChIKeyRVJLYMOGPFRCQZ-QGZVFWFLSA-N
Compound NameN-[6-[(3R)-3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]piperidine-1-carbonyl]-3-pyridinyl]prop-2-enamide
Canonical SMILESC=CC(=O)Nc1ccc(C(=O)N2CCC[C@@H](Nc3ncc(Cl)c(-c4c[nH]c5ccccc45)n3)C2)nc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)8
Pfam Stratification Cross-Family
Avg pChEMBL6.22
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (8)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9NYV4 CDK12 Homo sapiens Human PF00069 6.6 IC50 ChEMBL;BindingDB
O75909 CCNK Homo sapiens Human PF00134 PF21797 6.4 IC50 ChEMBL
O60563 CCNT1 Homo sapiens Human PF00134 PF21797 6.3 IC50 ChEMBL;BindingDB
P50750 CDK9 Homo sapiens Human PF00069 6.3 IC50 ChEMBL
Q14004 CDK13 Homo sapiens Human PF00069 6.1 IC50 ChEMBL;BindingDB
P50613 CDK7 Homo sapiens Human PF00069 6.0 IC50 ChEMBL
P51946 CCNH Homo sapiens Human PF16899 PF00134 6.0 IC50 ChEMBL;BindingDB
P51948 MNAT1 Homo sapiens Human PF25811 PF06391 PF17121 6.0 IC50 ChEMBL