Molecule Details
| InChIKey | RRGUKTPIGVIEKM-UHFFFAOYSA-N |
|---|---|
| Canonical SMILES | O=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.71 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01166 |
|---|---|
| Drug Name | Cilostazol |
| CAS Number | 73963-72-1 |
| Groups | approved investigational |
| ATC Codes | B01AC23 |
| Description | Cilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by ... |
Categories: Agents producing tachycardia Anti-Asthmatic Agents Antiplatelet agents Autonomic Agents Blood and Blood Forming Organs Bronchodilator Agents Cardiovascular Agents Central Nervous System Agents Compounds used in a research, industrial, or household setting Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Enzyme Inhibitors Fibrin Modulating Agents Hematologic Agents Heterocyclic Compounds, Fused-Ring Neuroprotective Agents Peripheral Nervous System Agents Phosphodiesterase 3 Inhibitors Phosphodiesterase Inhibitors Platelet Aggregation Inhibitors Excl. Heparin Potential QTc-Prolonging Agents Protective Agents QTc Prolonging Agents Quinolines Respiratory System Agents Tetrazoles Vasodilating Agents
Cross-references: BindingDB: 50225508 ChEBI: 31401 CHEMBL799 ChemSpider: 2652 D01896 PharmGKB: PA164746334 PubChem:2754 PubChem:46506317 RxCUI: 21107 Therapeutic Targets Database: DAP000191 Wikipedia: Cilostazol ZINC: ZINC000001552174
Target Activities (2)
DrugBank Target Actions (7)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P05177 | CYP1A2 | Cytochrome P450 1A2 | substrate | enzymes |
| P08684 | CYP3A4 | Cytochrome P450 3A4 | substrate | enzymes |
| P10635 | CYP2D6 | Cytochrome P450 2D6 | substrate | enzymes |
| P20815 | CYP3A5 | Cytochrome P450 3A5 | substrate | enzymes |
| P24462 | CYP3A7 | Cytochrome P450 3A7 | substrate | enzymes |
| P33261 | CYP2C19 | Cytochrome P450 2C19 | substrate | enzymes |
| Q14432 | PDE3A | cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A | inhibitor | targets |