Molecule Details
InChIKeyRRGUKTPIGVIEKM-UHFFFAOYSA-N
Canonical SMILESO=C1CCc2cc(OCCCCc3nnnn3C3CCCCC3)ccc2N1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)2
Pfam Stratification Homologous
Avg pChEMBL6.71
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB01166
Drug NameCilostazol
CAS Number73963-72-1
Groups approved investigational
ATC Codes B01AC23
DescriptionCilostazol is a quinolinone derivative and antiplatelet agent with vasodilating properties that has been used in the symptomatic treatment of intermittent claudication in patients with peripheral ischaemia. It is marketed under the brand name Pletal by Otsuka Pharmaceutical Co.. Cilostazol works by ...

Categories: Agents producing tachycardia Anti-Asthmatic Agents Antiplatelet agents Autonomic Agents Blood and Blood Forming Organs Bronchodilator Agents Cardiovascular Agents Central Nervous System Agents Compounds used in a research, industrial, or household setting Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Enzyme Inhibitors Fibrin Modulating Agents Hematologic Agents Heterocyclic Compounds, Fused-Ring Neuroprotective Agents Peripheral Nervous System Agents Phosphodiesterase 3 Inhibitors Phosphodiesterase Inhibitors Platelet Aggregation Inhibitors Excl. Heparin Potential QTc-Prolonging Agents Protective Agents QTc Prolonging Agents Quinolines Respiratory System Agents Tetrazoles Vasodilating Agents
Cross-references: BindingDB: 50225508 ChEBI: 31401 CHEMBL799 ChemSpider: 2652 D01896 PharmGKB: PA164746334 PubChem:2754 PubChem:46506317 RxCUI: 21107 Therapeutic Targets Database: DAP000191 Wikipedia: Cilostazol ZINC: ZINC000001552174
Target Activities (2)
Target Gene Organism Category Pfam pChEMBL Type Source
Q14432 PDE3A Homo sapiens Human PF00233 6.7 IC50 ChEMBL;BindingDB
Q13370 PDE3B Homo sapiens Human PF00233 6.7 IC50 ChEMBL
DrugBank Target Actions (7)
Target Gene Target Name Action Type
P05177 CYP1A2 Cytochrome P450 1A2 substrate enzymes
P08684 CYP3A4 Cytochrome P450 3A4 substrate enzymes
P10635 CYP2D6 Cytochrome P450 2D6 substrate enzymes
P20815 CYP3A5 Cytochrome P450 3A5 substrate enzymes
P24462 CYP3A7 Cytochrome P450 3A7 substrate enzymes
P33261 CYP2C19 Cytochrome P450 2C19 substrate enzymes
Q14432 PDE3A cGMP-inhibited 3',5'-cyclic phosphodiesterase 3A inhibitor targets