Molecule Details
| InChIKey | RQQJJXVETXFINY-UHFFFAOYSA-N |
|---|---|
| Compound Name | Hexamethylene amiloride |
| Canonical SMILES | N=C(N)NC(=O)c1nc(Cl)c(N2CCCCCC2)nc1N |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.31 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P19634 | SLC9A1 | Homo sapiens | Human | PF00999 PF16644 | 9.7 | IC50 | ChEMBL |
| Q96D31 | ORAI1 | Homo sapiens | Human | PF07856 | 7.3 | Ki | BindingDB |
| P29274 | ADORA2A | Homo sapiens | Human | PF00001 | 6.6 | IC50 | ChEMBL;BindingDB |
| P29275 | ADORA2B | Homo sapiens | Human | PF00001 | 6.6 | IC50 | ChEMBL |
| Q14940 | SLC9A5 | Homo sapiens | Human | PF00999 | 6.4 | Ki | ChEMBL |