Molecule Details
InChIKeyRQJIDUOCLNMUHR-UHFFFAOYSA-N
Compound Name1-(8-Fluoroquinolin-4-yl)-3-[6-(trifluoromethyl)pyridin-2-yl]urea
Canonical SMILESO=C(Nc1cccc(C(F)(F)F)n1)Nc1ccnc2c(F)cccc12
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)15
Pfam Stratification Cross-Family
Avg pChEMBL7.0
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (15)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9HAZ1 CLK4 Homo sapiens Human PF00069 7.9 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 7.7 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 7.5 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 7.4 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 7.4 Ki ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 7.3 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 7.1 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.9 Ki ChEMBL
P42685 FRK Homo sapiens Human PF07714 PF00017 PF00018 6.9 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 6.8 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.7 Ki ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.7 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.4 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.0 Ki ChEMBL