Molecule Details
| InChIKey | RQBXIYXQKQNKEN-UHFFFAOYSA-N |
|---|---|
| Compound Name | 5-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]thiophene-2-sulfonamide |
| Canonical SMILES | NS(=O)(=O)c1ccc(-c2nccc(Nc3cc(C4CC4)[nH]n3)n2)s1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 8.11 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P20248 | CCNA2 | Homo sapiens | Human | PF02984 PF00134 PF16500 | 8.2 | Ki | ChEMBL |
| P24941 | CDK2 | Homo sapiens | Human | PF00069 | 8.2 | Ki | ChEMBL;BindingDB |
| P9WI81 | pknB | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Pathogen | PF03793 PF00069 | 8.4 | Ki | ChEMBL;BindingDB |
| P9WI83 | pknA | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) | Pathogen | PF00069 | 7.7 | Ki | ChEMBL;BindingDB |