Molecule Details
| InChIKey | RPLGLPFQGFBRBL-IBGZPJMESA-N |
|---|---|
| Compound Name | (2S)-1-[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-phenyl-2-pyrrolidinecarboxamide |
| Canonical SMILES | O=C(Nc1ccccc1)[C@@H]1CCCN1c1nc(Nc2cc(C3CC3)[nH]n2)c2cccn2n1 |
| Clinical Status | Clinical Multi-Target |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.77 |
| Source | ChEMBL;BindingDB;TTD_MultiTarget |
2D Structure
Activity Profile
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P08069 | IGF1R | Homo sapiens | Human | PF00757 PF07714 PF01030 | 7.9 | IC50 | ChEMBL;BindingDB |
| O96020 | CCNE2 | Homo sapiens | Human | PF02984 PF00134 | 6.5 | IC50 | ChEMBL |
| P06729 | CD2 | Homo sapiens | Human | PF05790 PF07686 | 6.5 | pIC50 | TTD_MultiTarget |
| P24864 | CCNE1 | Homo sapiens | Human | PF02984 PF00134 | 6.5 | IC50 | ChEMBL |
| P24941 | CDK2 | Homo sapiens | Human | PF00069 | 6.5 | pIC50 | TTD_MultiTarget |