trans-4-(4-Amino-3-iodo-pyrazolo[3,4-d]pyrimidin-1-yl)-cyclohexanol

InChIKey	`RPGBQFNDFPEOON-UHFFFAOYSA-N`
Compound Name	trans-4-(4-Amino-3-iodo-pyrazolo[3,4-d]pyrimidin-1-yl)-cyclohexanol
Canonical SMILES	`Nc1ncnc2c1c(I)nn2C1CCC(O)CC1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	22
Pfam Stratification	Cross-Family
Avg pChEMBL	6.42
Source	ChEMBL

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
Q9HAZ1	CLK4	Homo sapiens	Human	PF00069	7.8	Ki	ChEMBL
P08922	ROS1	Homo sapiens	Human	PF00041 PF07714	7.5	Ki	ChEMBL
P49760	CLK2	Homo sapiens	Human	PF00069	7.1	Ki	ChEMBL
P48730	CSNK1D	Homo sapiens	Human	PF00069	7.0	Ki	ChEMBL
P48729	CSNK1A1	Homo sapiens	Human	PF00069	6.8	Ki	ChEMBL
Q13627	DYRK1A	Homo sapiens	Human	PF00069	6.6	Ki	ChEMBL
P51451	BLK	Homo sapiens	Human	PF07714 PF00017 PF00018	6.5	Ki	ChEMBL
O60674	JAK2	Homo sapiens	Human	PF18379 PF18377 PF17887 PF07714 PF21990	6.4	Ki	ChEMBL
P06241	FYN	Homo sapiens	Human	PF07714 PF00017 PF00018	6.4	Ki	ChEMBL
P30530	AXL	Homo sapiens	Human	PF00041 PF13927 PF07714	6.3	Ki	ChEMBL
O00444	PLK4	Homo sapiens	Human	PF00069 PF18190 PF18409	6.2	Ki	ChEMBL
P04629	NTRK1	Homo sapiens	Human	PF13855 PF16920 PF07714 PF18613	6.2	Ki	ChEMBL
P07949	RET	Homo sapiens	Human	PF00028 PF07714 PF17756 PF17812 PF17813 PF22540	6.2	Ki	ChEMBL
O43781	DYRK3	Homo sapiens	Human	PF00069	6.1	Ki	ChEMBL
P23443	RPS6KB1	Homo sapiens	Human	PF00069 PF00433	6.1	Ki	ChEMBL
Q9H2G2	SLK	Homo sapiens	Human	PF00069 PF12474	6.1	Ki	ChEMBL
P06213	INSR	Homo sapiens	Human	PF00757 PF17870 PF07714 PF01030	6.0	Ki	ChEMBL
P12931	SRC	Homo sapiens	Human	PF07714 PF00017 PF00018	6.0	Ki	ChEMBL
P16591	FER	Homo sapiens	Human	PF00611 PF07714 PF00017	6.0	Ki	ChEMBL
P24941	CDK2	Homo sapiens	Human	PF00069	6.0	Ki	ChEMBL
P29317	EPHA2	Homo sapiens	Human	PF14575 PF25599 PF01404 PF00041 PF07714 PF00536	6.0	Ki	ChEMBL
Q16288	NTRK3	Homo sapiens	Human	PF07679 PF00047 PF13855 PF16920 PF01462 PF07714	6.0	Ki	ChEMBL