1-[2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethyl]-5-(naphthalen-1-yl)-1,2,3,6-tetrahydropyridine-4-carbonitrile

InChIKey	`ROYSOBXGDVHDTQ-UHFFFAOYSA-N`
Compound Name	1-[2-(4-cyanophenyl)-2-hydroxy-2-(1-methyl-1H-imidazol-5-yl)ethyl]-5-(naphthalen-1-yl)-1,2,3,6-tetrahydropyridine-4-carbonitrile
Canonical SMILES	`Cn1cncc1C(O)(CN1CCC(C#N)=C(c2cccc3ccccc23)C1)c1ccc(C#N)cc1`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	5
Pfam Stratification	Cross-Family
Avg pChEMBL	8.2
Source	BindingDB;ChEMBL;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P49354	FNTA	Homo sapiens	Human	PF01239	9.3	pIC50	TTD_MultiTarget
P49356	FNTB	Homo sapiens	Human	PF00432	9.3	IC50	ChEMBL
P53609	PGGT1B	Homo sapiens	Human	PF00432	6.3	IC50	ChEMBL
Q5E175	rhlE	Aliivibrio fischeri (strain ATCC 700601 / ES114)	Pathogen	PF00270 PF00271	8.1	IC50	BindingDB
Q5EI73		Plasmodium falciparum	Pathogen	PF01239	8.1	IC50	ChEMBL