Molecule Details
InChIKeyROTWSDMXHVGAHZ-QZTJIDSGSA-N
Compound NameAtuliflapon
Canonical SMILESCc1cc(-c2ccc(C(=O)[C@@H]3CCCC[C@H]3C(=O)Nc3cnn4c3C(=O)NCC4)cc2)n[nH]1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL8.2
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB19029
Drug NameAtuliflapon
CAS Number2041075-86-7
Groups investigational
ATC Codes nan
DescriptionAtuliflapon is under investigation in clinical trial NCT05251259 (Study to Assess the Efficacy and Safety of Atuliflapon in Moderate-to-severe Uncontrolled Asthma).

Cross-references: BindingDB: 50524102 CHEMBL4542281 ChemSpider: 88297158
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
P09917 ALOX5 Homo sapiens Human PF00305 PF01477 8.2 IC50 ChEMBL;BindingDB
P20292 ALOX5AP Homo sapiens Human PF01124 8.2 IC50 ChEMBL;BindingDB
P39748 FEN1 Homo sapiens Human PF00867 PF00752 8.2 IC50 ChEMBL