InChIKey	RONZAEMNMFQXRA-UHFFFAOYSA-N
Compound Name	Mirtazapine
Canonical SMILES	CN1CCN2c3ncccc3Cc3ccccc3C2C1
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	9
Pfam Stratification	Homologous
Avg pChEMBL	7.58
Source	BindingDB;ChEMBL;TTD_MultiTarget

DrugBank ID	DB00370
Drug Name	Mirtazapine
CAS Number	85650-52-8
Groups	approved investigational
ATC Codes	N06AX11
Description	Mirtazapine is a tetracyclic _piperazino-azepine_ antidepressant agent that was initially approved for the treatment of major depressive disorder (MDD) in the Netherlands in 1994.[A177946] This drug was first manufactured by Organon Inc., and received FDA approval in 1997 for the treatment of major ...

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Categories: Adrenergic Agents Adrenergic Antagonists Adrenergic alpha-2 Receptor Antagonists Adrenergic alpha-Antagonists Agents that produce hypertension Anti-Anxiety Agents Antidepressive Agents Antidepressive Agents Indicated for Depression Antidepressive Agents, Second-Generation Antidepressive Agents, Tetracyclic Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (weak) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Heterocyclic Compounds, Fused-Ring Histamine Agents Histamine Antagonists Histamine H1 Antagonists Miscellaneous Antidepressants Nervous System Neurotransmitter Agents Potential QTc-Prolonging Agents Psychoanaleptics Psychotropic Drugs QTc Prolonging Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin 5-HT2C Receptor Antagonists Serotonin 5-HT3 Receptor Antagonists Serotonin Agents Serotonin Modulators Serotonin Receptor Antagonists Tranquilizing Agents

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Cross-references: BindingDB: 50115644 ChEBI: 6950 CHEMBL654 ChemSpider: 4060 Drugs Product Database (DPD): 12209 C07570 D00563 PharmGKB: PA450522 PubChem:4205 PubChem:46506965 RxCUI: 15996 Therapeutic Targets Database: DAP000010 Wikipedia: Mirtazapine