Molecule Details
InChIKeyRMUCZJUITONUFY-UHFFFAOYSA-N
Compound NamePhenelzine
Canonical SMILESNNCCc1ccccc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)5
Pfam Stratification Cross-Family
Avg pChEMBL6.68
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00780
Drug NamePhenelzine
CAS Number51-71-8
Groups approved investigational
ATC Codes N06AF03
DescriptionPhenelzine, with the formula β-phenylethylhydrazine, is a monoamine oxidase inhibiting antidepressant that is effective in the treatment of panic disorder and social anxiety disorder.[A15753] It was developed by Parke Davis and originally FDA approved on June 9th, 1961. It is currently approved unde...
Categories: Agents that produce hypertension Agents that reduce seizure threshold Antidepressive Agents Antidepressive Agents Indicated for Depression Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Inhibitors Cytochrome P-450 CYP2C8 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2E1 Inducers Cytochrome P-450 CYP2E1 Inducers (strength unknown) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (strength unknown) Cytochrome P-450 CYP3A7 Inhibitors Cytochrome P-450 CYP3A7 Inhibitors (strength unknown) Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Drugs that are Mainly Renally Excreted Enzyme Inhibitors Hydrazines Hypotensive Agents Monoamine Oxidase A Substrates Monoamine Oxidase Inhibitors Monoamine Oxidase Inhibitors, Non-Selective Nervous System Psychoanaleptics Psychotropic Drugs Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin Agents Serotonin Modulators
Cross-references: BindingDB: 50105417 ChEBI: 8060 CHEMBL1089 ChemSpider: 3547 Drugs Product Database (DPD): 11355 C07430 D08349 PharmGKB: PA450903 PubChem:3675 PubChem:46507348 RxCUI: 8123 Therapeutic Targets Database: DAP000578 Wikipedia: Phenelzine ZINC: ZINC000019166991
Target Activities (5)
Target Gene Organism Category Pfam pChEMBL Type Source
Q16853 AOC3 Homo sapiens Human PF01179 PF02727 PF02728 7.7 IC50 ChEMBL;BindingDB
P27338 MAOB Homo sapiens Human PF01593 6.9 Ki ChEMBL;BindingDB
P21397 MAOA Homo sapiens Human PF01593 6.7 IC50 ChEMBL;BindingDB
P33261 CYP2C19 Homo sapiens Human PF00067 6.1 IC50 ChEMBL
P10635 CYP2D6 Homo sapiens Human PF00067 6.0 IC50 ChEMBL
DrugBank Target Actions (16)
Target Gene Target Name Action Type
P05181 CYP2E1 Cytochrome P450 2E1 inducer enzymes
P08684 CYP3A4 Cytochrome P450 3A4 inhibitor enzymes
P10632 CYP2C8 Cytochrome P450 2C8 inhibitor enzymes
P10635 CYP2D6 Cytochrome P450 2D6 inhibitor enzymes
P20815 CYP3A5 Cytochrome P450 3A5 inhibitor enzymes
P24462 CYP3A7 Cytochrome P450 3A7 inhibitor enzymes
P33261 CYP2C19 Cytochrome P450 2C19 inhibitor enzymes
P21397 MAOA Amine oxidase [flavin-containing] A substrate enzymes
P27338 MAOB Amine oxidase [flavin-containing] B substrate enzymes
P21397 MAOA Amine oxidase [flavin-containing] A antagonist targets
P27338 MAOB Amine oxidase [flavin-containing] B antagonist targets
P24298 P24298 Alanine aminotransferase 1 inhibitor targets
P80404 ABAT 4-aminobutyrate aminotransferase, mitochondrial inhibitor targets
Q16853 AOC3 Amine oxidase [copper-containing] 3 inhibitor targets
Q8TD30 Q8TD30 Alanine aminotransferase 2 inhibitor targets
Q9UGI5 Q9UGI5 Glutamate decarboxylase 2 inhibitor targets