Molecule Details
InChIKeyRMTJSBZCZKCYHB-UHFFFAOYSA-N
Compound Name1-[4-[[4-Amino-5-(1,3-benzodioxol-5-yl)pyrrolo[2,3-d]pyrimidin-7-yl]methyl]piperidin-1-yl]prop-2-en-1-one
Canonical SMILESC=CC(=O)N1CCC(Cn2cc(-c3ccc4c(c3)OCO4)c3c(N)ncnc32)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)13
Pfam Stratification Cross-Family
Avg pChEMBL6.58
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
Target Activities (13)
Target Gene Organism Category Pfam pChEMBL Type Source
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 7.7 IC50 ChEMBL
P05177 CYP1A2 Homo sapiens Human PF00067 7.2 IC50 ChEMBL;BindingDB
P51813 BMX Homo sapiens Human PF00779 PF00169 PF07714 PF00017 7.2 IC50 ChEMBL;BindingDB
P07947 YES1 Homo sapiens Human PF07714 PF00017 PF00018 6.8 IC50 ChEMBL;BindingDB
Q92570 NR4A3 Homo sapiens Human PF00104 PF00105 6.7 IC50 ChEMBL;BindingDB
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.6 IC50 ChEMBL;BindingDB
P42681 TXK Homo sapiens Human PF07714 PF00017 PF00018 6.5 IC50 ChEMBL;BindingDB
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.3 IC50 ChEMBL;BindingDB
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.2 IC50 ChEMBL;BindingDB
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.2 IC50 ChEMBL;BindingDB
P09769 FGR Homo sapiens Human PF07714 PF00017 PF00018 6.2 IC50 ChEMBL;BindingDB
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 6.0 IC50 ChEMBL
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.0 IC50 ChEMBL