Molecule Details
| InChIKey | RMMXLENWKUUMAY-UHFFFAOYSA-N |
|---|---|
| Compound Name | Telmisartan |
| Canonical SMILES | CCCc1nc2c(C)cc(-c3nc4ccccc4n3C)cc2n1Cc1ccc(-c2ccccc2C(=O)O)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.72 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00966 |
|---|---|
| Drug Name | Telmisartan |
| CAS Number | 144701-48-4 |
| Groups | approved investigational |
| ATC Codes | C09DB04 C10BX20 C09CA07 C09DX08 C09DA07 |
| Description | Telmisartan is an angiotensin II receptor antagonist (ARB) used in the management of hypertension. Generally, angiotensin II receptor blockers (ARBs) such as telmisartan bind to the angiotensin II type 1 (AT1) receptors with high affinity, causing inhibition of the action of angiotensin II on vascul... |
Categories: Agents Acting on the Renin-Angiotensin System Agents causing angioedema Agents causing hyperkalemia Angiotensin 2 Receptor Blocker Angiotensin II Type 1 Receptor Blockers Angiotensin II Type 2 Receptor Blockers Angiotensin II receptor antagonists Angiotensin II receptor blockers (ARBs) and calcium channel blockers Angiotensin II receptor blockers (ARBs) and diuretics Angiotensin II receptor blockers (ARBs), plain Angiotensin Receptor Antagonists Antihypertensive Agents Antihypertensive Agents Indicated for Hypertension BCRP/ABCG2 Inhibitors BSEP/ABCB11 Substrates Benzene Derivatives Benzimidazoles Biphenyl Compounds Cardiovascular Agents Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Hypotensive Agents Lipid Modifying Agents P-glycoprotein inhibitors UGT1A3 substrates
Cross-references: BindingDB: 50043280 ChEBI: 9434 CHEMBL1017 ChemSpider: 59391 Drugs Product Database (DPD): 11907 Guide to Pharmacology: 592 IUPHAR: 592 C07710 D00627 PDB: TLS PharmGKB: PA451605 PubChem:65999 PubChem:46505370 RxCUI: 73494 Therapeutic Targets Database: DAP000766 Wikipedia: Telmisartan ZINC: ZINC000001530886
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P50052 | AGTR2 | Homo sapiens | Human | PF00001 | 9.5 | IC50 | ChEMBL;BindingDB |
| P30556 | AGTR1 | Homo sapiens | Human | PF00001 | 9.0 | IC50 | ChEMBL;BindingDB |
| P51589 | CYP2J2 | Homo sapiens | Human | PF00067 | 6.4 | IC50 | ChEMBL;BindingDB |
| Q9NPD5 | SLCO1B3 | Homo sapiens | Human | PF07648 PF03137 | 6.0 | Ki | ChEMBL;BindingDB |
DrugBank Target Actions (8)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P33261 | CYP2C19 | Cytochrome P450 2C19 | inhibitor | enzymes |
| P35503 | P35503 | UDP-glucuronosyltransferase 1A3 | substrate | enzymes |
| P30556 | AGTR1 | Type-1 angiotensin II receptor | antagonist | targets |
| P37231 | PPARG | Peroxisome proliferator-activated receptor gamma | partial agonist | targets |
| P08183 | ABCB1 | ATP-dependent translocase ABCB1 | inhibitor | transporters |
| Q92887 | ABCC2 | ATP-binding cassette sub-family C member 2 | inhibitor | transporters |
| Q9UNQ0 | ABCG2 | Broad substrate specificity ATP-binding cassette transporter ABCG2 | inhibitor | transporters |
| O95342 | ABCB11 | Bile salt export pump | substrate | transporters |