Molecule Details
| InChIKey | RMHMFHUVIITRHF-UHFFFAOYSA-N |
|---|---|
| Compound Name | Pirenzepine |
| Canonical SMILES | CN1CCN(CC(=O)N2c3ccccc3C(=O)Nc3cccnc32)CC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.09 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00670 |
|---|---|
| Drug Name | Pirenzepine |
| CAS Number | 28797-61-7 |
| Groups | approved withdrawn |
| ATC Codes | A02BX03 |
| Description | An antimuscarinic agent that inhibits gastric secretion at lower doses than are required to affect gastrointestinal motility, salivary, central nervous system, cardiovascular, ocular, and urinary function. It promotes the healing of duodenal ulcers and due to its cytoprotective action is beneficial ... |
Categories: Agents producing tachycardia Alimentary Tract and Metabolism Anti-Ulcer Agents Anticholinergic Agents Benzazepines Benzodiazepinones Cholinergic Agents Drugs for Acid Related Disorders Drugs for Peptic Ulcer and Gastro-Oesophageal Reflux Disease (Gord) Gastrointestinal Agents Heterocyclic Compounds, Fused-Ring Muscarinic Antagonists Neurotransmitter Agents
Cross-references: BindingDB: 39341 ChEBI: 8247 CHEMBL9967 ChemSpider: 4682 Drugs Product Database (DPD): 20323 C07508 D08389 PharmGKB: PA10159 PubChem:4848 PubChem:46509029 RxCUI: 8352 Therapeutic Targets Database: DAP000492 Wikipedia: Pirenzepine ZINC: ZINC000019632927
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P11229 | CHRM1 | Homo sapiens | Human | PF00001 | 7.7 | Ki | ChEMBL;BindingDB |
| P08173 | CHRM4 | Homo sapiens | Human | PF00001 | 7.5 | Ki | ChEMBL;BindingDB |
| P08912 | CHRM5 | Homo sapiens | Human | PF00001 | 6.9 | Ki | ChEMBL;BindingDB |
| P20309 | CHRM3 | Homo sapiens | Human | PF00001 | 6.8 | Ki | ChEMBL;BindingDB |
| P08172 | CHRM2 | Homo sapiens | Human | PF00001 | 6.6 | Ki | ChEMBL;BindingDB |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P11229 | CHRM1 | Muscarinic acetylcholine receptor M1 | antagonist | targets |