Molecule Details
InChIKeyRKUNBYITZUJHSG-SPUOUPEWSA-N
Canonical SMILESCN1[C@@H]2CC[C@H]1C[C@@H](OC(=O)C(CO)c1ccccc1)C2
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Homologous
Avg pChEMBL8.19
SourceChEMBL
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB00572
Drug NameAtropine
CAS Number51-55-8
Groups approved investigational vet_approved
ATC Codes S01FA01 A03CB03 V03AB54 A03BA01
DescriptionAtropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intr...

Categories: Adjuvants, Anesthesia Agents producing tachycardia Agents that produce hypertension Alimentary Tract and Metabolism Alkaloids Anti-Asthmatic Agents Antiarrhythmic agents Anticholinergic Agents Antidotes Antimuscarinics Antispasmodics Autonomic Agents Aza Compounds Azabicyclo Compounds BSEP/ABCB11 Substrates Belladonna Alkaloids Belladonna Alkaloids, Tertiary Amines Belladonna and Derivatives, Plain Bronchodilator Agents Cardiovascular Agents Central Nervous System Agents Cholinergic Agents Drugs for Functional Gastrointestinal Disorders Moderate Risk QTc-Prolonging Agents Muscarinic Antagonists Mydriatics Mydriatics and Cycloplegics Neurotransmitter Agents Ophthalmologicals Parasympatholytics Peripheral Nervous System Agents QTc Prolonging Agents Respiratory System Agents Sensory Organs Solanaceous Alkaloids Tropanes
Cross-references: BindingDB: 50403547 ChEBI: 78734 CHEMBL517712 ChemSpider: 10194105 Drugs Product Database (DPD): 8970 Guide to Pharmacology: 320 IUPHAR: 320 C01479 D00113 PDB: OIN PharmGKB: PA448505 PubChem:174174 PubChem:46507540 RxCUI: 1223 Therapeutic Targets Database: DAP000377 Wikipedia: Atropine
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
P08173 CHRM4 Homo sapiens Human PF00001 9.1 Ki ChEMBL
P08912 CHRM5 Homo sapiens Human PF00001 9.1 Ki ChEMBL
P11229 CHRM1 Homo sapiens Human PF00001 9.1 Ki ChEMBL
P20309 CHRM3 Homo sapiens Human PF00001 9.1 Ki ChEMBL
P08172 CHRM2 Homo sapiens Human PF00001 8.8 Ki ChEMBL
P25100 ADRA1D Homo sapiens Human PF00001 6.2 Ki ChEMBL
P28335 HTR2C Homo sapiens Human PF00001 6.1 IC50 ChEMBL
DrugBank Target Actions (10)
Target Gene Target Name Action Type
P02763 P02763 Alpha-1-acid glycoprotein 1 binder carriers
P08172 CHRM2 Muscarinic acetylcholine receptor M2 antagonist targets
P08173 CHRM4 Muscarinic acetylcholine receptor M4 antagonist targets
P08912 CHRM5 Muscarinic acetylcholine receptor M5 antagonist targets
P11229 CHRM1 Muscarinic acetylcholine receptor M1 antagonist targets
P20309 CHRM3 Muscarinic acetylcholine receptor M3 antagonist targets
P23415 GLRA1 Glycine receptor subunit alpha-1 antagonist targets
P17787 CHRNB2 Neuronal acetylcholine receptor subunit beta-2 substrate targets
P43681 CHRNA4 Neuronal acetylcholine receptor subunit alpha-4 substrate targets
O95342 ABCB11 Bile salt export pump substrate transporters