Molecule Details
InChIKeyRJZDECGDCKOHBV-UHFFFAOYSA-N
Compound Name2-[2-(2-Phenylethenyl)-4-pyridinyl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one
Canonical SMILESO=C1NCCc2[nH]c(-c3ccnc(C=Cc4ccccc4)c3)cc21
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)70
Pfam Stratification Cross-Family
Avg pChEMBL6.91
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (70)
Target Gene Organism Category Pfam pChEMBL Type Source
O94806 PRKD3 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 8.4 Ki ChEMBL
P78368 CSNK1G2 Homo sapiens Human PF12605 PF00069 8.4 Ki ChEMBL
P51957 NEK4 Homo sapiens Human PF00069 8.3 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 8.3 Ki ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 8.2 Ki ChEMBL
O43781 DYRK3 Homo sapiens Human PF00069 8.1 Ki ChEMBL
Q9BZL6 PRKD2 Homo sapiens Human PF00130 PF00169 PF00069 PF25525 8.1 Ki ChEMBL
P08581 MET Homo sapiens Human PF07714 PF01437 PF01403 PF01833 7.9 Ki ChEMBL
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 7.8 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 7.8 Ki ChEMBL
Q9HBH9 MKNK2 Homo sapiens Human PF00069 7.8 Ki ChEMBL
O43293 DAPK3 Homo sapiens Human PF00069 7.7 Ki ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 7.6 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 7.5 Ki ChEMBL
P48730 CSNK1D Homo sapiens Human PF00069 7.5 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 7.5 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 7.4 Ki ChEMBL
Q8TDC3 BRSK1 Homo sapiens Human PF21122 PF00069 PF21115 7.4 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 7.3 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 7.3 Ki ChEMBL
P48729 CSNK1A1 Homo sapiens Human PF00069 7.3 Ki ChEMBL
P45983 MAPK8 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q8IW41 MAPKAPK5 Homo sapiens Human PF00069 7.2 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 7.2 Ki ChEMBL
O15530 PDPK1 Homo sapiens Human PF14593 PF00069 7.1 Ki ChEMBL
P45984 MAPK9 Homo sapiens Human PF00069 7.1 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 7.1 Ki ChEMBL
O00311 CDC7 Homo sapiens Human PF00069 7.0 Ki ChEMBL
O15111 CHUK Homo sapiens Human PF18397 PF12179 PF00069 6.9 Ki ChEMBL
O15264 MAPK13 Homo sapiens Human PF00069 6.9 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.9 Ki ChEMBL
O14920 IKBKB Homo sapiens Human PF18397 PF12179 PF00069 6.8 Ki ChEMBL
P15735 PHKG2 Homo sapiens Human PF00069 6.8 Ki ChEMBL
Q9NYL2 MAP3K20 Homo sapiens Human PF07714 PF07647 6.8 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.7 Ki ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.6 Ki ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P11309 PIM1 Homo sapiens Human PF00069 6.6 Ki ChEMBL
P53778 MAPK12 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 6.6 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q9BXA7 TSSK1B Homo sapiens Human PF00069 6.6 Ki ChEMBL
Q9H2X6 HIPK2 Homo sapiens Human PF00069 6.6 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.5 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 6.5 Ki ChEMBL
Q96SB4 SRPK1 Homo sapiens Human PF00069 6.5 Ki ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 6.4 Ki ChEMBL
P00533 EGFR Homo sapiens Human PF00757 PF14843 PF07714 PF01030 PF21314 6.4 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q14680 MELK Homo sapiens Human PF02149 PF00069 PF21594 6.4 Ki ChEMBL
O14757 CHEK1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.3 Ki ChEMBL
P28482 MAPK1 Homo sapiens Human PF00069 6.3 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.3 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.3 Ki ChEMBL
P52333 JAK3 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.3 Ki ChEMBL
P53350 PLK1 Homo sapiens Human PF00069 PF00659 6.3 Ki ChEMBL
Q96PF2 TSSK2 Homo sapiens Human PF00069 6.3 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 6.3 Ki ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 6.3 Ki ChEMBL
O60674 JAK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.2 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 6.2 Ki ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.2 Ki ChEMBL
P51955 NEK2 Homo sapiens Human PF00069 6.2 Ki ChEMBL
Q14289 PTK2B Homo sapiens Human PF21477 PF00373 PF18038 PF03623 PF07714 6.2 Ki ChEMBL
P23443 RPS6KB1 Homo sapiens Human PF00069 PF00433 6.1 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 6.1 Ki ChEMBL
Q7L7X3 TAOK1 Homo sapiens Human PF00069 6.0 Ki ChEMBL
Q9H4B4 PLK3 Homo sapiens Human PF00069 PF00659 6.0 Ki ChEMBL
Q9HBY8 SGK2 Homo sapiens Human PF00069 PF00433 6.0 Ki ChEMBL