InChIKey	RJURFGZVJUQBHK-IIXSONLDSA-N
Canonical SMILES	Cc1c2oc3c(C)ccc(C(=O)N[C@@H]4C(=O)N[C@H](C(C)C)C(=O)N5CCC[C@H]5C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]4C)c3nc-2c(C(=O)N[C@@H]2C(=O)N[C@H](C(C)C)C(=O)N3CCC[C@H]3C(=O)N(C)CC(=O)N(C)[C@@H](C(C)C)C(=O)O[C@@H]2C)c(N)c1=O
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	2
Pfam Stratification	Cross-Family
Avg pChEMBL	7.09
Source	BindingDB

DrugBank ID	DB00970
Drug Name	Dactinomycin
CAS Number	50-76-0
Groups	approved investigational
ATC Codes	L01DA01
Description	A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, prot...

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Categories: Actinomycin Actinomycines Amino Acids, Peptides, and Proteins Anti-Infective Agents Antibiotics, Antineoplastic Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Substrates Cytotoxic Antibiotics and Related Substances Cytotoxins Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Immunosuppressive Agents Myelosuppressive Agents Narrow Therapeutic Index Drugs Nucleic Acid Synthesis Inhibitors P-glycoprotein inhibitors P-glycoprotein substrates P-glycoprotein substrates with a Narrow Therapeutic Index Peptides Peptides, Cyclic Protein Synthesis Inhibitors

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Cross-references: BindingDB: 50089528 ChEBI: 27666 CHEMBL1554 ChemSpider: 10482167 Drugs Product Database (DPD): 8486 C06770 D00214 PharmGKB: PA151917012 PubChem:457193 PubChem:46509192 RxCUI: 3100 Therapeutic Targets Database: DNC000380 Wikipedia: Dactinomycin