InChIKey	RJKFOVLPORLFTN-LEKSSAKUSA-N
Compound Name	Progesterone
Canonical SMILES	CC(=O)[C@H]1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3CC[C@]12C
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	10
Pfam Stratification	Cross-Family
Avg pChEMBL	8.07
Source	ChEMBL;BindingDB;TTD_MultiTarget

DrugBank ID	DB00396
Drug Name	Progesterone
CAS Number	57-83-0
Groups	approved investigational vet_approved
ATC Codes	G03FA04 G03DA04
Description	Progesterone is a hormone that occurs naturally in females, and is essential for endometrial receptivity, embryo implantation, and the successful establishment of pregnancy. A low progesterone concentration or an insufficient response to progesterone can cause infertility and pregnancy loss [A175609...

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Categories: Adrenal Cortex Hormones BCRP/ABCG2 Inducers BCRP/ABCG2 Inhibitors BSEP/ABCB11 Inhibitors Corpus Luteum Hormones Cytochrome P-450 CYP1A1 Substrates Cytochrome P-450 CYP2A6 Inducers Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A7 Inhibitors Cytochrome P-450 CYP3A7 Inhibitors (strength unknown) Cytochrome P-450 CYP3A7 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Fused-Ring Compounds Genito Urinary System and Sex Hormones Gonadal Hormones Gonadal Steroid Hormones Hormonal Contraceptives for Systemic Use Hormones Hormones, Hormone Substitutes, and Hormone Antagonists Hyperglycemia-Associated Agents OATP1B1/SLCO1B1 Inhibitors OATP1B3 inducers OCT1 inhibitors OCT2 Inhibitors P-glycoprotein inducers P-glycoprotein inhibitors P-glycoprotein substrates Pregnanes Pregnenediones Pregnenes Progesterone and Derivatives Progesterone, antagonists & inhibitors Progestin-containing Intrauterine Device Progestins Sex Hormones and Modulators of the Genital System Steroids

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Cross-references: BindingDB: 8903 ChEBI: 17026 CHEMBL103 ChemSpider: 5773 Drugs Product Database (DPD): 7554 C00410 D00066 PDB: STR PharmGKB: PA451123 PubChem:5994 PubChem:46508968 RxCUI: 8727 Therapeutic Targets Database: DAP000549 Wikipedia: Progesterone ZINC: ZINC000004428529