Molecule Details
InChIKeyRITAVMQDGBJQJZ-UHFFFAOYSA-N
Compound NameN-Methyl-2-({3-[2-(pyridin-2-yl)ethenyl]-1H-indazol-6-yl}sulfanyl)benzamide
Canonical SMILESCNC(=O)c1ccccc1Sc1ccc2c(C=Cc3ccccn3)n[nH]c2c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)33
Pfam Stratification Cross-Family
Avg pChEMBL7.06
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (33)
Target Gene Organism Category Pfam pChEMBL Type Source
P09619 PDGFRB Homo sapiens Human PF00047 PF13927 PF25305 PF07714 9.2 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 8.5 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 8.4 Ki ChEMBL
P16234 PDGFRA Homo sapiens Human PF07679 PF25305 PF07714 8.2 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 8.1 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 8.1 Ki ChEMBL
P10721 KIT Homo sapiens Human PF00047 PF07714 8.0 Ki ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 7.7 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.7 Ki ChEMBL
Q5S007 LRRK2 Homo sapiens Human PF23745 PF23744 PF23748 PF16095 PF25497 PF13855 PF00069 PF08477 7.7 Ki ChEMBL
O14965 AURKA Homo sapiens Human PF00069 7.4 Kd ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 7.3 Ki ChEMBL
P22607 FGFR3 Homo sapiens Human PF21165 PF07679 PF13927 PF07714 7.2 Ki ChEMBL
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 7.1 Ki ChEMBL
O95819 MAP4K4 Homo sapiens Human PF00780 PF00069 6.8 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 6.8 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 6.8 Ki ChEMBL
Q04912 MST1R Homo sapiens Human PF07714 PF01437 PF01403 PF01833 6.6 Ki ChEMBL
Q13131 PRKAA1 Homo sapiens Human PF16579 PF21147 PF00069 6.6 Ki ChEMBL
Q8TDC3 BRSK1 Homo sapiens Human PF21122 PF00069 PF21115 6.6 Ki ChEMBL
Q9H2G2 SLK Homo sapiens Human PF00069 PF12474 6.6 Ki ChEMBL
Q9Y4K4 MAP4K5 Homo sapiens Human PF00780 PF00069 6.6 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.5 Ki ChEMBL
P29597 TYK2 Homo sapiens Human PF18379 PF18377 PF17887 PF07714 PF21990 6.5 Ki ChEMBL
Q12851 MAP4K2 Homo sapiens Human PF00780 PF00069 6.5 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 6.4 Ki ChEMBL
Q8N4C8 MINK1 Homo sapiens Human PF00780 PF00069 6.4 Ki ChEMBL
P51451 BLK Homo sapiens Human PF07714 PF00017 PF00018 6.3 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.3 Ki ChEMBL
P51812 RPS6KA3 Homo sapiens Human PF00069 PF00433 6.1 Ki ChEMBL
P53667 LIMK1 Homo sapiens Human PF00412 PF00595 PF07714 6.1 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.0 Ki ChEMBL
Q16513 PKN2 Homo sapiens Human PF02185 PF00069 PF00433 6.0 Ki ChEMBL