InChIKey	RITAVMQDGBJQJZ-FMIVXFBMSA-N
Compound Name	Axitinib
Canonical SMILES	CNC(=O)c1ccccc1Sc1ccc2c(/C=C/c3ccccn3)n[nH]c2c1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	43
Pfam Stratification	Cross-Family
Avg pChEMBL	7.07
Source	BindingDB;ChEMBL

DrugBank ID	DB06626
Drug Name	Axitinib
CAS Number	319460-85-0
Groups	approved investigational
ATC Codes	L01EK01
Description	Axitinib is a second generation tyrosine kinase inhibitor that works by selectively inhibiting vascular endothelial growth factor receptors (VEGFR-1, VEGFR-2, VEGFR-3).[L6676] Through this mechanism of action, axitinib blocks angiogenesis, tumour growth and metastases. It is reported to exhibit pote...

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Categories: Acids, Carbocyclic Amides Antineoplastic Agents Antineoplastic and Immunomodulating Agents Benzamides and benzamide derivatives Benzene Derivatives Benzoates Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C19 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index Cytochrome P-450 CYP3A5 Substrates Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Substrates Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Indazoles Kinase Inhibitor Narrow Therapeutic Index Drugs OATP1B1/SLCO1B1 Inhibitors OATP1B1/SLCO1B1 Substrates P-glycoprotein inhibitors P-glycoprotein substrates P-glycoprotein substrates with a Narrow Therapeutic Index Protein Kinase Inhibitors Pyrazoles Receptor Tyrosine Kinase Inhibitors Tyrosine Kinase Inhibitors UGT1A1 Substrates UGT1A1 Substrates with a Narrow Therapeutic Index Vascular endothelial growth factor receptor (VEGFR) tyrosine kinase inhibitors

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Cross-references: BindingDB: 25117 ChEBI: 66910 CHEMBL1289926 ChemSpider: 4953153 Drugs Product Database (DPD): 21398 D03218 PDB: AXI PharmGKB: PA164924493 PubChem:6450551 PubChem:347827779 RxCUI: 1242999 Wikipedia: Axitinib ZINC: ZINC000003816287