2-[[6-(4-acetylpiperazin-1-yl)-2-methylpyrimidin-4-yl]amino]-N-(2-chloro-4-methylthiophen-3-yl)-1,3-thiazole-5-carboxamide

InChIKey	`RIJYZTZQMRSSEU-UHFFFAOYSA-N`
Compound Name	2-[[6-(4-acetylpiperazin-1-yl)-2-methylpyrimidin-4-yl]amino]-N-(2-chloro-4-methylthiophen-3-yl)-1,3-thiazole-5-carboxamide
Canonical SMILES	`CC(=O)N1CCN(c2cc(Nc3ncc(C(=O)Nc4c(C)csc4Cl)s3)nc(C)n2)CC1`
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Homologous
Avg pChEMBL	7.34
Source	ChEMBL;BindingDB

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P57059	SIK1	Homo sapiens	Human	PF00069 PF23312	7.7	IC50	ChEMBL;BindingDB
Q9H0K1	SIK2	Homo sapiens	Human	PF00069 PF23312	7.6	IC50	ChEMBL;BindingDB
Q9Y2K2	SIK3	Homo sapiens	Human	PF00069 PF23312	6.8	IC50	ChEMBL;BindingDB