InChIKey	RHWKPHLQXYSBKR-BMIGLBTASA-N
Compound Name	Dolutegravir
Canonical SMILES	C[C@@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	3
Pfam Stratification	Cross-Family
Avg pChEMBL	7.59
Source	BindingDB;ChEMBL

DrugBank ID	DB08930
Drug Name	Dolutegravir
CAS Number	1051375-16-6
Groups	approved investigational
ATC Codes	J05AR29 J05AR27 J05AJ03 J05AR13 J05AR25 J05AR21
Description	Dolutegravir is an HIV-1 integrase inhibitor that blocks the strand transfer step of the integration of the viral genome into the host cell (INSTI).[A7514] The effect of this drug has no homology in human host cells, which gives it excellent tolerability and minimal toxicity.[A31342] Dolutegravir wa...

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Categories: Anti-HIV Agents Anti-Infective Agents Anti-Retroviral Agents Antiinfectives for Systemic Use Antiviral Agents Antivirals for Systemic Use Antivirals used in combination for the treatment of HIV infections BCRP/ABCG2 Substrates Direct Acting Antivirals Enzyme Inhibitors HIV Integrase Inhibitors Heterocyclic Compounds, Fused-Ring Human Immunodeficiency Virus Integrase Strand Transfer Inhibitor Integrase Inhibitors MATE 1 Inhibitors MATE inhibitors OAT1/SLC22A6 inhibitors OAT3/SLC22A8 Inhibitors OCT2 Inhibitors P-glycoprotein substrates UGT1A1 Substrates UGT1A3 substrates UGT1A9 Substrates

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Cross-references: BindingDB: 50062551 ChEBI: 76010 CHEMBL1229211 ChemSpider: 25051637 Drugs Product Database (DPD): 21556 D10066 PDB: DLU PharmGKB: PA166114961 PubChem:54726191 PubChem:175427161 RxCUI: 1433868 Wikipedia: Dolutegravir ZINC: ZINC000058581064