Molecule Details
| InChIKey | RFWZESUMWJKKRN-UHFFFAOYSA-N |
|---|---|
| Compound Name | Dapiprazole |
| Canonical SMILES | Cc1ccccc1N1CCN(CCc2nnc3n2CCCC3)CC1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 5 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 6.71 |
| Source | ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB00298 |
|---|---|
| Drug Name | Dapiprazole |
| CAS Number | 72822-12-9 |
| Groups | approved |
| ATC Codes | S01EX02 |
| Description | Dapiprazole (U.S. trade name Rev-Eyes) is an alpha blocker. It is found in ophthalmic solutions used to reverse mydriasis after an eye examination. |
Categories: Adrenergic Agents Adrenergic Antagonists Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Agents that produce hypertension Antiglaucoma Preparations and Miotics Antipsychotic Agents Central Nervous System Agents Central Nervous System Depressants Neurotoxic agents Neurotransmitter Agents Ophthalmics Ophthalmologicals Sensory Organs Tranquilizing Agents
Cross-references: ChEBI: 51066 CHEMBL1201216 ChemSpider: 2298190 D07775 PharmGKB: PA164749109 PubChem:3033538 PubChem:46508859 RxCUI: 22298 Therapeutic Targets Database: DAP000298 Wikipedia: Dapiprazole ZINC: ZINC000000001246
Target Activities (5)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P25100 | ADRA1D | Homo sapiens | Human | PF00001 | 8.2 | IC50 | ChEMBL |
| P28223 | HTR2A | Homo sapiens | Human | PF00001 | 6.5 | IC50 | ChEMBL |
| P28335 | HTR2C | Homo sapiens | Human | PF00001 | 6.3 | IC50 | ChEMBL |
| P18089 | ADRA2B | Homo sapiens | Human | PF00001 | 6.3 | Ki | ChEMBL |
| P41595 | HTR2B | Homo sapiens | Human | PF00001 | 6.2 | Ki | ChEMBL |