Molecule Details
InChIKeyRFTSSZJZXOSICM-GRSHGNNSSA-N
Canonical SMILESCOC1=CC(c2cc3ccccc3[nH]2)=N/C1=C\c1[nH]c(C)cc1C
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)5
Pfam Stratification Cross-Family
Avg pChEMBL6.0
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB12191
Drug NameObatoclax
CAS Number803712-67-6
Groups investigational
ATC Codes nan
DescriptionObatoclax has been used in trials studying the treatment of AML, Leukemia, Myelofibrosis, Hodgkin's Lymphoma, and Mantle-Cell Lymphoma, among others.

Categories: Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring
Cross-references: BindingDB: 50376902 CHEMBL408194 ChemSpider: 21430401 PubChem:11404337 PubChem:347828476 Wikipedia: Obatoclax ZINC: ZINC000029052268
Target Activities (5)
Target Gene Organism Category Pfam pChEMBL Type Source
Q07820 MCL1 Homo sapiens Human PF00452 6.0 Ki ChEMBL;BindingDB
Q16548 BCL2A1 Homo sapiens Human PF00452 6.0 Ki ChEMBL;BindingDB
Q92843 BCL2L2 Homo sapiens Human PF00452 PF02180 6.0 Ki ChEMBL;BindingDB
Q92934 BAD Homo sapiens Human PF10514 6.0 Ki ChEMBL;BindingDB
Q9HD36 BCL2L10 Homo sapiens Human PF00452 6.0 Ki ChEMBL;BindingDB
DrugBank Target Actions (3)
Target Gene Target Name Action Type
P10415 BCL2 Apoptosis regulator Bcl-2 inhibitor targets
Q07817 BCL2L1 Bcl-2-like protein 1 inhibitor targets
Q07820 MCL1 Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitor targets