InChIKey	RFHAOTPXVQNOHP-UHFFFAOYSA-N
Compound Name	Fluconazole
Canonical SMILES	OC(Cn1cncn1)(Cn1cncn1)c1ccc(F)cc1F
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	4
Pfam Stratification	Homologous
Avg pChEMBL	6.72
Source	BindingDB;ChEMBL

DrugBank ID	DB00196
Drug Name	Fluconazole
CAS Number	86386-73-4
Groups	approved investigational
ATC Codes	J01RA07 J02AC01 D01AC15
Description	Fluconazole, commonly known as _Diflucan_, is an antifungal drug used for the treatment of both systemic and superficial fungal infections in a variety of tissues. It was initially approved by the FDA in 1990. This drug is an _azole_ antifungal, in the same drug family as [ketoconazole] and [itracon...

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Categories: 14-alpha Demethylase Inhibitors Agents causing hyperkalemia Anti-Infective Agents Antifungal Agents Antifungals for Dermatological Use Antifungals for Topical Use Antiinfectives for Systemic Use Antimycotics for Systemic Use Azole Antifungals Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C9 Inhibitors Cytochrome P-450 CYP2C9 Inhibitors (strong) Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (moderate) Cytochrome P-450 CYP3A5 Inhibitors Cytochrome P-450 CYP3A5 Inhibitors (weak) Cytochrome P-450 Enzyme Inhibitors Dermatologicals Drugs that are Mainly Renally Excreted Enzyme Inhibitors Hormone Antagonists Hormones, Hormone Substitutes, and Hormone Antagonists Imidazole and Triazole Derivatives P-glycoprotein inhibitors Potential QTc-Prolonging Agents QTc Prolonging Agents Steroid Synthesis Inhibitors Triazole Derivatives Triazole and tetrazole derivatives Triazoles

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Cross-references: BindingDB: 25817 ChEBI: 46081 CHEMBL106 ChemSpider: 3248 Drugs Product Database (DPD): 1204 D00322 PDB: TPF PharmGKB: PA449653 PubChem:3365 PubChem:46505735 RxCUI: 4450 Therapeutic Targets Database: DAP000628 Wikipedia: Fluconazole ZINC: ZINC000000004009