Molecule Details
| InChIKey | REZGGXNDEMKIQB-UHFFFAOYSA-N |
|---|---|
| Compound Name | Zaprinast |
| Canonical SMILES | CCCOc1ccccc1-c1nc2[nH]nnc2c(=O)[nH]1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 8 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.4 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB20746 |
|---|---|
| Drug Name | Zaprinast |
| CAS Number | 37762-06-4 |
| Groups | experimental |
| ATC Codes | nan |
| Description | Zaprinast is a small molecule drug. Zaprinast has a monoisotopic molecular weight of 271.11 Da. |
Categories: Enzyme Inhibitors Heterocyclic Compounds, Fused-Ring Phosphodiesterase Inhibitors Purines
Cross-references: BindingDB: 50612246 ChEBI: 92215 CHEMBL28079 PDB: A1IL3 ZINC: ZINC000014953365
Target Activities (8)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| O76074 | PDE5A | Homo sapiens | Human | PF01590 PF00233 | 6.4 | IC50 | ChEMBL;BindingDB |
| O43924 | PDE6D | Homo sapiens | Human | PF05351 | 6.4 | Ki | ChEMBL |
| P16499 | PDE6A | Homo sapiens | Human | PF01590 PF00233 | 6.4 | Ki | ChEMBL |
| P18545 | PDE6G | Homo sapiens | Human | PF04868 | 6.4 | Ki | ChEMBL |
| P35913 | PDE6B | Homo sapiens | Human | PF01590 PF00233 | 6.4 | Ki | ChEMBL |
| P51160 | PDE6C | Homo sapiens | Human | PF01590 PF00233 | 6.4 | Ki | ChEMBL;BindingDB |
| Q13956 | PDE6H | Homo sapiens | Human | PF04868 | 6.4 | Ki | ChEMBL |
| Q9HC97 | GPR35 | Homo sapiens | Human | PF00001 | 6.4 | Ki | ChEMBL;BindingDB |