Molecule Details
| InChIKey | REQCZEXYDRLIBE-UHFFFAOYSA-N |
|---|---|
| Compound Name | Procainamide |
| Canonical SMILES | CCN(CC)CCNC(=O)c1ccc(N)cc1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.9 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01035 |
|---|---|
| Drug Name | Procainamide |
| CAS Number | 51-06-9 |
| Groups | approved |
| ATC Codes | C01BA02 |
| Description | A derivative of procaine with less CNS action. |
Categories: Acids, Carbocyclic Agents Causing Muscle Toxicity Agents that produce neuromuscular block (indirect) Amides Aminobenzoates Antiarrhythmic agents Antiarrhythmics, Class I Antiarrhythmics, Class Ia Benzamides and benzamide derivatives Benzene Derivatives Benzoates Cardiac Therapy Cardiovascular Agents Cholinesterase Inhibitors Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Substrates Drugs that are Mainly Renally Excreted Drugs that are Mainly Renally Excreted with a Narrow Therapeutic Index Highest Risk QTc-Prolonging Agents MATE 1 Substrates MATE 1 Substrates with a Narrow Therapeutic Index MATE 2 Substrates MATE 2 Substrates with a Narrow Therapeutic Index MATE substrates Membrane Transport Modulators Narrow Therapeutic Index Drugs Negative Inotrope OCT1 inhibitors OCT2 Inhibitors OCT2 Substrates with a Narrow Therapeutic Index QTc Prolonging Agents Sodium Channel Blockers Voltage-Gated Sodium Channel Blockers para-Aminobenzoates
Cross-references: BindingDB: 39344 ChEBI: 8428 CHEMBL640 ChemSpider: 4744 Drugs Product Database (DPD): 9702 C07401 PharmGKB: PA451108 PubChem:4913 PubChem:46507313 RxCUI: 8700 Therapeutic Targets Database: DAP000516 Wikipedia: Procainamide ZINC: ZINC000001530756
Target Activities (2)
DrugBank Target Actions (12)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P06276 | BCHE | Cholinesterase | inhibitor | enzymes |
| P10635 | CYP2D6 | Cytochrome P450 2D6 | substrate | enzymes |
| Q12809 | KCNH2 | Voltage-gated inwardly rectifying potassium channel KCNH2 | inhibitor | targets |
| Q14524 | SCN5A | Sodium channel protein type 5 subunit alpha | inhibitor | targets |
| P26358 | DNMT1 | DNA (cytosine-5)-methyltransferase 1 | other | targets |
| O15244 | SLC22A2 | Solute carrier family 22 member 2 | inhibitor | transporters |
| O15245 | SLC22A1 | Solute carrier family 22 member 1 | inhibitor | transporters |
| O75751 | SLC22A3 | Solute carrier family 22 member 3 | inhibitor | transporters |
| O76082 | O76082 | Organic cation/carnitine transporter 2 | inhibitor | transporters |
| Q9H015 | Q9H015 | Solute carrier family 22 member 4 | inhibitor | transporters |
| Q86VL8 | SLC47A2 | Multidrug and toxin extrusion protein 2 | substrate | transporters |
| Q96FL8 | SLC47A1 | Multidrug and toxin extrusion protein 1 | substrate | transporters |