InChIKey	RDOIQAHITMMDAJ-UHFFFAOYSA-N
Compound Name	Loperamide
Canonical SMILES	CN(C)C(=O)C(CCN1CCC(O)(c2ccc(Cl)cc2)CC1)(c1ccccc1)c1ccccc1
Clinical Status	Data-mined Candidate
Targets (Human+Pathogen)	13
Pfam Stratification	Cross-Family
Avg pChEMBL	6.89
Source	BindingDB;ChEMBL

DrugBank ID	DB00836
Drug Name	Loperamide
CAS Number	53179-11-6
Groups	approved investigational
ATC Codes	A07DA53 A07DA03
Description	Loperamide is an anti-diarrheal agent that is available as an over-the-counter product for treating diarrhea.[L42785] The drug was first synthesized in 1969 and used medically in 1976.[A251610] It is a highly lipophilic synthetic phenylpiperidine opioid that works by binding to mu-opioid receptors o...

---

Categories: Agents causing hyperkalemia Alimentary Tract and Metabolism Antiarrhythmic agents Antidiarrheals Antidiarrheals, Intestinal Antiinflammatory/antiinfective Agents Antipropulsives Bradycardia-Causing Agents Cytochrome P-450 CYP2B6 Substrates Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (strength unknown) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Gastrointestinal Agents Moderate Risk QTc-Prolonging Agents Opioid Agonist P-glycoprotein substrates Piperidines QTc Prolonging Agents

---

Cross-references: BindingDB: 50017698 ChEBI: 6532 CHEMBL841 ChemSpider: 3818 Drugs Product Database (DPD): 2251 C07080 D08144 PharmGKB: PA450262 PubChem:3955 PubChem:46504591 RxCUI: 6468 Therapeutic Targets Database: DAP000425 Wikipedia: Loperamide ZINC: ZINC000000537928