Molecule Details
| InChIKey | RDNFSVWPIOKLKD-CSMHCCOUSA-N |
|---|---|
| Compound Name | [[(2S,3R,5S)-5-(4-amino-5-methyl-2-oxo-pyrimidin-1-yl)-3-fluoro-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate |
| Canonical SMILES | Cc1cn([C@@H]2C[C@@H](F)[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O2)c(=O)nc1N |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.58 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P09884 | POLA1 | Homo sapiens | Human | PF12254 PF00136 PF03104 PF08996 | 7.8 | IC50 | ChEMBL;BindingDB |
| P54098 | POLG | Homo sapiens | Human | PF18136 | 6.3 | IC50 | ChEMBL;BindingDB |
| P06746 | POLB | Homo sapiens | Human | PF14792 PF14791 PF10391 PF14716 | 6.0 | IC50 | ChEMBL |
| Q72547 | pol | Human immunodeficiency virus type 1 | Pathogen | PF00075 PF00078 PF06815 PF06817 | 6.2 | IC50 | ChEMBL;BindingDB |