Molecule Details
InChIKeyRAXZSEGXMBWYQK-SNVBAGLBSA-N
Compound NameERK-IN-2 (free base)
Canonical SMILESC[C@@H](NC(=O)Nc1cc2[nH]ncc2c(CO)n1)c1ccccc1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)21
Pfam Stratification Cross-Family
Avg pChEMBL6.78
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (21)
Target Gene Organism Category Pfam pChEMBL Type Source
P27361 MAPK3 Homo sapiens Human PF00069 8.8 Kd ChEMBL
Q8TD08 MAPK15 Homo sapiens Human PF00069 7.5 Kd ChEMBL
P37173 TGFBR2 Homo sapiens Human PF08917 PF07714 7.3 Kd ChEMBL
Q9NRM7 LATS2 Homo sapiens Human PF00069 PF00433 7.3 Kd ChEMBL
O75116 ROCK2 Homo sapiens Human PF25346 PF00069 PF08912 7.1 Kd ChEMBL
Q13464 ROCK1 Homo sapiens Human PF25346 PF00069 PF08912 7.0 Kd ChEMBL
P25098 GRK2 Homo sapiens Human PF00169 PF00069 PF00615 7.0 Kd ChEMBL
Q8TF76 HASPIN Homo sapiens Human PF12330 6.9 Kd ChEMBL
O75385 ULK1 Homo sapiens Human PF12063 PF21127 PF00069 6.8 Kd ChEMBL
P35626 GRK3 Homo sapiens Human PF00169 PF00069 PF00615 6.8 Kd ChEMBL
P49840 GSK3A Homo sapiens Human PF00069 6.7 IC50 ChEMBL
P28482 MAPK1 Homo sapiens Human PF00069 6.7 IC50 ChEMBL
P50613 CDK7 Homo sapiens Human PF00069 6.6 Kd ChEMBL
Q9HAZ1 CLK4 Homo sapiens Human PF00069 6.6 Kd ChEMBL
O00141 SGK1 Homo sapiens Human PF00069 PF00433 6.6 IC50 ChEMBL
P49841 GSK3B Homo sapiens Human PF00069 6.3 IC50 ChEMBL
Q9UHD2 TBK1 Homo sapiens Human PF00069 PF18394 PF18396 6.1 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.1 IC50 ChEMBL
Q9P289 STK26 Homo sapiens Human PF20929 PF00069 6.1 IC50 ChEMBL
P49760 CLK2 Homo sapiens Human PF00069 6.0 IC50 ChEMBL
Q13237 PRKG2 Homo sapiens Human PF00027 PF00069 6.0 IC50 ChEMBL