Molecule Details
| InChIKey | RAQDXJIIWQPIQJ-KRWDZBQOSA-N |
|---|---|
| Compound Name | (3S)-1-[3-[1-(2-fluoroprop-2-enoyl)azetidin-3-yl]-1-[4-(trifluoromethoxy)phenyl]pyrazolo[3,4-b]pyridin-4-yl]-3-hydroxy-pyrrolidin-2-one |
| Canonical SMILES | C=C(F)C(=O)N1CC(c2nn(-c3ccc(OC(F)(F)F)cc3)c3nccc(N4CC[C@H](O)C4=O)c23)C1 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.2 |
| Source | BindingDB |
2D Structure
Activity Profile
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q15561 | TEAD4 | Homo sapiens | Human | PF01285 PF17725 | 8.3 | IC50 | BindingDB |
| P28347 | TEAD1 | Homo sapiens | Human | PF01285 PF17725 | 7.5 | IC50 | BindingDB |
| Q99594 | TEAD3 | Homo sapiens | Human | PF01285 PF17725 | 6.6 | IC50 | BindingDB |
| Q15562 | TEAD2 | Homo sapiens | Human | PF01285 PF17725 | 6.4 | IC50 | BindingDB |