Molecule Details
InChIKeyRAPYFGJGASETOS-UHFFFAOYSA-N
Compound Name1-[4-(2,4-Diaminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)urea
Canonical SMILESCc1cccc(NC(=O)Nc2ccc(-c3csc4nc(N)nc(N)c34)cc2)c1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)11
Pfam Stratification Cross-Family
Avg pChEMBL7.18
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (11)
Target Gene Organism Category Pfam pChEMBL Type Source
P07333 CSF1R Homo sapiens Human PF00047 PF25305 PF07714 8.5 Ki ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 8.5 Ki ChEMBL
P36888 FLT3 Homo sapiens Human PF00047 PF07714 8.1 Ki ChEMBL
P35968 KDR Homo sapiens Human PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854 7.6 Ki ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.1 Ki ChEMBL
P30530 AXL Homo sapiens Human PF00041 PF13927 PF07714 7.0 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.8 Ki ChEMBL
Q96GD4 AURKB Homo sapiens Human PF00069 6.7 Ki ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 6.3 Ki ChEMBL
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 6.2 Ki ChEMBL
Q8NE63 HIPK4 Homo sapiens Human PF00069 6.2 Ki ChEMBL