InChIKey	QZUDBNBUXVUHMW-UHFFFAOYSA-N
Compound Name	Clozapine
Canonical SMILES	CN1CCN(C2=Nc3cc(Cl)ccc3Nc3ccccc32)CC1
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	39
Pfam Stratification	Cross-Family
Avg pChEMBL	7.2
Source	BindingDB;ChEMBL;TTD_MultiTarget

DrugBank ID	DB00363
Drug Name	Clozapine
CAS Number	5786-21-0
Groups	approved investigational
ATC Codes	N05AH02
Description	Clozapine is a tricyclic dibenzodiazepine, classified as an atypical antipsychotic agent.[A256708] Clozapine displays affinity to various neuroreceptors with a particularly low affinity to the dopamine receptors, thus breaking the mold of first-generation antipsychotics and deeming it "atypical".[A2...

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Categories: Adrenergic Antagonists Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Agents producing tachycardia Agents that produce hypertension Agents that reduce seizure threshold Anticholinergic Agents Antidepressive Agents Antipsychotic Agents Antipsychotic Agents (Second Generation [Atypical]) Central Nervous System Agents Central Nervous System Depressants Cytochrome P-450 CYP1A2 Substrates Cytochrome P-450 CYP2A6 Substrates Cytochrome P-450 CYP2C19 Inhibitors Cytochrome P-450 CYP2C19 Inhibitors (weak) Cytochrome P-450 CYP2C19 Substrates Cytochrome P-450 CYP2C19 inhibitors (strength unknown) Cytochrome P-450 CYP2C8 Substrates Cytochrome P-450 CYP2C9 Substrates Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (moderate) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP3A Inducers Cytochrome P-450 CYP3A Inhibitors Cytochrome P-450 CYP3A Substrates Cytochrome P-450 CYP3A4 Inducers Cytochrome P-450 CYP3A4 Inducers (strength unknown) Cytochrome P-450 CYP3A4 Inhibitors Cytochrome P-450 CYP3A4 Inhibitors (moderate) Cytochrome P-450 CYP3A4 Substrates Cytochrome P-450 Enzyme Inducers Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Diazepines, Oxazepines, Thiazepines and Oxepines Dibenzazepines Dopamine Antagonists Dopamine D2 Receptor Antagonists Drugs causing inadvertant photosensitivity Drugs that are Mainly Renally Excreted GABA Agents GABA Antagonists Heterocyclic Compounds, Fused-Ring Histamine Antagonists Histamine H1 Antagonists Hyperglycemia-Associated Agents Hypotensive Agents Moderate Risk QTc-Prolonging Agents Muscarinic Antagonists Nervous System Neurotoxic agents Neurotransmitter Agents OCT1 substrates P-glycoprotein substrates Photosensitizing Agents Psycholeptics Psychotropic Drugs QTc Prolonging Agents Serotonin 5-HT1 Receptor Antagonists Serotonin 5-HT1A Receptor Antagonists Serotonin 5-HT1D Receptor Antagonists Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin 5-HT2C Receptor Antagonists Serotonin Agents Serotonin Receptor Antagonists Tranquilizing Agents UGT1A4 substrates

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Cross-references: BindingDB: 50001884 ChEBI: 3766 CHEMBL42 ChemSpider: 10442628 Drugs Product Database (DPD): 1196 Guide to Pharmacology: 38 IUPHAR: 38 C06924 D00283 PDB: VBU PharmGKB: PA449061 PubChem:2818 PubChem:46506474 RxCUI: 2626 Therapeutic Targets Database: DAP000029 Wikipedia: Clozapine ZINC: ZINC000019796155