Molecule Details
| InChIKey | QZAYGJVTTNCVMB-UHFFFAOYSA-N |
|---|---|
| Compound Name | Serotonin |
| Canonical SMILES | NCCc1c[nH]c2ccc(O)cc12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 17 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 7.51 |
| Source | BindingDB;ChEMBL |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB08839 |
|---|---|
| Drug Name | Serotonin |
| CAS Number | 50-67-9 |
| Groups | investigational nutraceutical |
| ATC Codes | nan |
| Description | For temporary relief of nervousness, anxiety, mood swings, joint pains, weakness, drowsiness, itching and lethargy. Not evaluated by the FDA, homeopathic product. |
Categories: Amines Antidepressive Agents Autacoids Biogenic Amines Biogenic Monoamines Biological Factors Central Nervous System Depressants Complex Mixtures Endopeptidases Heterocyclic Compounds, Fused-Ring Indoles Inflammation Mediators Neurotransmitter Agents Serine Proteases Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin Agents Serotonin Receptor Agonists Snake Venoms Toxins, Biological Tryptamines Venoms Viper Venoms
Cross-references: BindingDB: 29524 ChEBI: 28790 CHEMBL39 ChemSpider: 5013 C00780 PDB: SRO RxCUI: 1311214 Wikipedia: Serotonin ZINC: ZINC000000057058
Target Activities (17)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P34969 | HTR7 | Homo sapiens | Human | PF00001 | 9.0 | Ki | ChEMBL;BindingDB |
| P08908 | HTR1A | Homo sapiens | Human | PF00001 | 8.6 | Ki | ChEMBL;BindingDB |
| P28221 | HTR1D | Homo sapiens | Human | PF00001 | 8.5 | Ki | ChEMBL;BindingDB |
| P28222 | HTR1B | Homo sapiens | Human | PF00001 | 8.2 | Ki | ChEMBL;BindingDB |
| P28566 | HTR1E | Homo sapiens | Human | PF00001 | 8.2 | Ki | ChEMBL;BindingDB |
| P30939 | HTR1F | Homo sapiens | Human | PF00001 | 8.0 | Ki | BindingDB |
| P41595 | HTR2B | Homo sapiens | Human | PF00001 | 7.9 | Ki | ChEMBL;BindingDB |
| P28335 | HTR2C | Homo sapiens | Human | PF00001 | 7.6 | Ki | ChEMBL;BindingDB |
| P50406 | HTR6 | Homo sapiens | Human | PF00001 | 7.1 | Ki | ChEMBL;BindingDB |
| P28223 | HTR2A | Homo sapiens | Human | PF00001 | 6.9 | Ki | ChEMBL;BindingDB |
| A5X5Y0 | HTR3E | Homo sapiens | Human | PF02931 PF02932 | 6.9 | Ki | ChEMBL |
| O95264 | HTR3B | Homo sapiens | Human | PF02931 PF02932 | 6.9 | Ki | ChEMBL |
| P46098 | HTR3A | Homo sapiens | Human | PF02931 PF02932 | 6.9 | Ki | ChEMBL |
| Q70Z44 | HTR3D | Homo sapiens | Human | PF02931 PF02932 | 6.9 | Ki | ChEMBL |
| Q8WXA8 | HTR3C | Homo sapiens | Human | PF02931 PF02932 | 6.9 | Ki | ChEMBL |
| P47898 | HTR5A | Homo sapiens | Human | PF00001 | 6.8 | IC50 | ChEMBL;BindingDB |
| Q13639 | HTR4 | Homo sapiens | Human | PF00001 | 6.6 | Ki | ChEMBL;BindingDB |
DrugBank Target Actions (16)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| P31645 | SLC6A4 | Sodium-dependent serotonin transporter | binder | targets |
| Q05940 | SLC18A2 | Synaptic vesicular amine transporter | binder | targets |
| O95264 | HTR3B | 5-hydroxytryptamine receptor 3B | inhibitor | targets |
| P08908 | HTR1A | 5-hydroxytryptamine receptor 1A | inhibitor | targets |
| P0DMS8 | ADORA3 | Adenosine receptor A3 | inhibitor | targets |
| P28221 | HTR1D | 5-hydroxytryptamine receptor 1D | inhibitor | targets |
| P28222 | HTR1B | 5-hydroxytryptamine receptor 1B | inhibitor | targets |
| P28223 | HTR2A | 5-hydroxytryptamine receptor 2A | inhibitor | targets |
| P28335 | HTR2C | 5-hydroxytryptamine receptor 2C | inhibitor | targets |
| P34969 | HTR7 | 5-hydroxytryptamine receptor 7 | inhibitor | targets |
| P41595 | HTR2B | 5-hydroxytryptamine receptor 2B | inhibitor | targets |
| P46098 | HTR3A | 5-hydroxytryptamine receptor 3A | inhibitor | targets |
| P47898 | HTR5A | 5-hydroxytryptamine receptor 5A | inhibitor | targets |
| P50406 | HTR6 | 5-hydroxytryptamine receptor 6 | inhibitor | targets |
| Q13639 | HTR4 | 5-hydroxytryptamine receptor 4 | inhibitor | targets |
| O15244 | SLC22A2 | Solute carrier family 22 member 2 | binder | transporters |