N-[3-[3-[[2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide

InChIKey	`QWLOMYFDXCOOFH-UHFFFAOYSA-N`
Compound Name	N-[3-[3-[[2-methyl-6-(4-methylpiperazin-1-yl)pyrimidin-4-yl]amino]-1H-pyrazol-5-yl]phenyl]benzenesulfonamide
Canonical SMILES	`Cc1nc(Nc2cc(-c3cccc(NS(=O)(=O)c4ccccc4)c3)n[nH]2)cc(N2CCN(C)CC2)n1`
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	5
Pfam Stratification	Cross-Family
Avg pChEMBL	6.87
Source	ChEMBL;BindingDB;TTD_MultiTarget

2D Structure

Activity Profile

Target	Gene	Organism	Category	Pfam	pChEMBL	Type	Source
P36888	FLT3	Homo sapiens	Human	PF00047 PF07714	8.2	IC50	ChEMBL;BindingDB
O14965	AURKA	Homo sapiens	Human	PF00069	6.5	IC50	ChEMBL;BindingDB
P35968	KDR	Homo sapiens	Human	PF07679 PF00047 PF13895 PF22971 PF07714 PF21339 PF17988 PF22854	6.5	IC50	ChEMBL;BindingDB
Q02161	RHD	Homo sapiens	Human	PF00909	6.5	pIC50	TTD_MultiTarget
P17948	FLT1	Homo sapiens	Human	PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854	6.5	IC50	ChEMBL;BindingDB