InChIKey	QWGDMFLQWFTERH-UHFFFAOYSA-N
Compound Name	Amoxapine
Canonical SMILES	Clc1ccc2c(c1)C(N1CCNCC1)=Nc1ccccc1O2
Clinical Status	Clinical Multi-Target
Targets (Human+Pathogen)	23
Pfam Stratification	Cross-Family
Avg pChEMBL	7.03
Source	ChEMBL;BindingDB;TTD_MultiTarget

DrugBank ID	DB00543
Drug Name	Amoxapine
CAS Number	14028-44-5
Groups	approved
ATC Codes	N06AA17
Description	Amoxapine, the <i>N</i>-demethylated derivative of the antipsychotic agent loxapine, is a dibenzoxazepine-derivative tricyclic antidepressant (TCA). TCAs are structurally similar to phenothiazines. They contain a tricyclic ring system with an alkyl amine substituent on the central ring. In non-depre...

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Categories: Adrenergic Agents Adrenergic Antagonists Adrenergic Uptake Inhibitors Adrenergic alpha-1 Receptor Antagonists Adrenergic alpha-Antagonists Agents producing tachycardia Agents that produce hypertension Agents that reduce seizure threshold Anticholinergic Agents Antidepressive Agents Antidepressive Agents Indicated for Depression Antidepressive Agents, Tetracyclic Antidepressive Agents, Tricyclic Antipsychotic Agents Central Nervous System Agents Central Nervous System Depressants Combined Inhibitors of Serotonin/Norepinephrine Reuptake Cytochrome P-450 CYP2D6 Inhibitors Cytochrome P-450 CYP2D6 Inhibitors (strength unknown) Cytochrome P-450 CYP2D6 Substrates Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Substrates Dibenzoxazepines Dopamine Agents Dopamine Antagonists Dopamine D2 Receptor Antagonists Heterocyclic Compounds, Fused-Ring Histamine Antagonists Histamine H1 Antagonists Membrane Transport Modulators Muscarinic Antagonists Narrow Therapeutic Index Drugs Nervous System Neurotoxic agents Neurotransmitter Agents Neurotransmitter Uptake Inhibitors Non-Selective Monoamine Reuptake Inhibitors P-glycoprotein inhibitors Potential QTc-Prolonging Agents Psychoanaleptics Psychotropic Drugs QTc Prolonging Agents Serotonergic Drugs Shown to Increase Risk of Serotonin Syndrome Serotonin 5-HT1 Receptor Antagonists Serotonin 5-HT1A Receptor Antagonists Serotonin 5-HT2 Receptor Antagonists Serotonin 5-HT2A Receptor Antagonists Serotonin 5-HT2C Receptor Antagonists Serotonin Agents Serotonin Modulators Serotonin Receptor Antagonists

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Cross-references: BindingDB: 22870 ChEBI: 2675 CHEMBL1113 ChemSpider: 2085 Drugs Product Database (DPD): 8001 Guide to Pharmacology: 201 IUPHAR: 201 D00228 PharmGKB: PA448405 PubChem:2170 PubChem:46509117 RxCUI: 722 Therapeutic Targets Database: DAP001149 Wikipedia: Amoxapine ZINC: ZINC000000000931