Molecule Details
| InChIKey | QVZCXCJXTMIDME-UHFFFAOYSA-N |
|---|---|
| Compound Name | Dilazep |
| Canonical SMILES | COc1cc(C(=O)OCCCN2CCCN(CCCOC(=O)c3cc(OC)c(OC)c(OC)c3)CC2)cc(OC)c1OC |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 4 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.6 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB13715 |
|---|---|
| Drug Name | Dilazep |
| CAS Number | 35898-87-4 |
| Groups | experimental |
| ATC Codes | C01DX10 |
| Description | nan |
Categories: Azepines Cardiac Therapy Cardiovascular Agents Vasodilating Agents Vasodilators Used in Cardiac Diseases
Cross-references: BindingDB: 50017691 ChEBI: 92842 CHEMBL126075 ChemSpider: 2965 PDB: 8DZ Wikipedia: Dilazep ZINC: ZINC000022454221
Target Activities (4)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| Q99808 | SLC29A1 | Homo sapiens | Human | PF01733 | 7.8 | IC50 | ChEMBL;BindingDB |
| P35498 | SCN1A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.2 | IC50 | ChEMBL;BindingDB |
| Q99250 | SCN2A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.2 | IC50 | ChEMBL |
| Q9NY46 | SCN3A | Homo sapiens | Human | PF00520 PF24609 PF06512 PF11933 | 6.2 | IC50 | ChEMBL |
DrugBank Target Actions (1)
| Target | Gene | Target Name | Action | Type |
|---|---|---|---|---|
| Q99808 | SLC29A1 | Equilibrative nucleoside transporter 1 | inhibitor | targets |