Molecule Details
InChIKeyQTBWCSQGBMPECM-UHFFFAOYSA-N
Compound NameGsk-1070916
Canonical SMILESCCn1cc(-c2ccnc3[nH]c(-c4cccc(CN(C)C)c4)cc23)c(-c2ccc(NC(=O)N(C)C)cc2)n1
Clinical Status Clinical Multi-Target
Targets (Human+Pathogen)21
Pfam Stratification Cross-Family
Avg pChEMBL7.19
SourceChEMBL;BindingDB;TTD_MultiTarget
2D Structure
2D structure
Activity Profile
Target Activities (21)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9NQS7 INCENP Homo sapiens Human PF03941 PF12178 8.8 Ki ChEMBL
Q9UQB9 AURKC Homo sapiens Human PF00069 8.5 IC50 ChEMBL;BindingDB
Q96GD4 AURKB Homo sapiens Human PF00069 8.5 IC50 ChEMBL;BindingDB
Q02763 TEK Homo sapiens Human PF00041 PF10430 PF07714 8.4 pIC50 TTD_MultiTarget
Q08345 DDR1 Homo sapiens Human PF21114 PF00754 PF07714 8.1 Kd ChEMBL
O75716 STK16 Homo sapiens Human PF00069 7.9 pIC50 TTD_MultiTarget
P11362 FGFR1 Homo sapiens Human PF07679 PF00047 PF07714 7.4 pIC50 TTD_MultiTarget
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.4 IC50 ChEMBL;BindingDB
P36888 FLT3 Homo sapiens Human PF00047 PF07714 7.3 Kd ChEMBL
P07949 RET Homo sapiens Human PF00028 PF07714 PF17756 PF17812 PF17813 PF22540 7.2 Kd ChEMBL
P57059 SIK1 Homo sapiens Human PF00069 PF23312 7.2 IC50 ChEMBL;BindingDB
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 7.1 IC50 ChEMBL;BindingDB
Q32MK0 MYLK3 Homo sapiens Human PF00069 7.0 Kd ChEMBL
Q9NSY1 BMP2K Homo sapiens Human PF15282 PF00069 6.8 Kd ChEMBL
O14965 AURKA Homo sapiens Human PF00069 6.3 Ki ChEMBL;BindingDB
Q9ULW0 TPX2 Homo sapiens Human PF09041 PF06886 PF12214 6.3 Ki ChEMBL;BindingDB
Q13470 TNK1 Homo sapiens Human PF07714 PF22931 6.3 Kd ChEMBL
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.2 Kd ChEMBL
O43353 RIPK2 Homo sapiens Human PF00619 PF07714 6.2 Kd ChEMBL
Q9H0K1 SIK2 Homo sapiens Human PF00069 PF23312 6.2 Kd ChEMBL
Q14164 IKBKE Homo sapiens Human PF00069 PF18394 PF18396 6.0 Kd ChEMBL