Molecule Details
| InChIKey | QSQQQURBVYWZKJ-UHFFFAOYSA-N |
|---|---|
| Compound Name | (+-)-alpha-Methyltryptamine |
| Canonical SMILES | CC(N)Cc1c[nH]c2ccccc12 |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 9 |
| Pfam Stratification | Cross-Family |
| Avg pChEMBL | 6.35 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB01446 |
|---|---|
| Drug Name | Indopan |
| CAS Number | 299-26-3 |
| Groups | experimental illicit |
| ATC Codes | nan |
| Description | Indopan (alpha-methyltryptamine) is a stimulant and psychoactive drug which produces effects similar to 3,4-methylenedioxy-N-methylamphetamine (MDMA), despite being structurally dissimilar. It was developed in the 1960's by Upjohn with the intention for use as an antidepressant. In the 1990's, indop... |
Categories: Amines Biogenic Amines Biogenic Monoamines Heterocyclic Compounds, Fused-Ring Indoles Stimulants
Cross-references: BindingDB: 50014210 ChEBI: 59020 CHEMBL30713 ChemSpider: 8930 PubChem:9287 PubChem:46507024 Wikipedia: Alpha-Methyltryptamine
Target Activities (9)
| Target | Gene | Organism | Category | Pfam | pChEMBL | Type | Source |
|---|---|---|---|---|---|---|---|
| P34969 | HTR7 | Homo sapiens | Human | PF00001 | 7.0 | Ki | ChEMBL |
| P28335 | HTR2C | Homo sapiens | Human | PF00001 | 6.8 | Ki | ChEMBL |
| P28223 | HTR2A | Homo sapiens | Human | PF00001 | 6.4 | Ki | ChEMBL |
| P28222 | HTR1B | Homo sapiens | Human | PF00001 | 6.3 | Ki | ChEMBL |
| P08913 | ADRA2A | Homo sapiens | Human | PF00001 | 6.2 | Ki | ChEMBL |
| P23975 | SLC6A2 | Homo sapiens | Human | PF00209 | 6.2 | Ki | ChEMBL |
| Q01959 | SLC6A3 | Homo sapiens | Human | PF00209 | 6.2 | Ki | ChEMBL |
| P31645 | SLC6A4 | Homo sapiens | Human | PF03491 PF00209 | 6.1 | Ki | ChEMBL |
| P50406 | HTR6 | Homo sapiens | Human | PF00001 | 6.0 | Ki | ChEMBL |