Molecule Details
InChIKeyQQUXFYAWXPMDOE-UHFFFAOYSA-N
Compound NameKenpaullone
Canonical SMILESO=C1Cc2c([nH]c3ccc(Br)cc23)-c2ccccc2N1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)31
Pfam Stratification Unknown
Avg pChEMBL6.65
SourceBindingDB;ChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (31)
Target Gene Organism Category Pfam pChEMBL Type Source
P28482 MAPK1 Homo sapiens Human PF00069 8.1 IC50 BindingDB
P49840 GSK3A Homo sapiens Human PF00069 7.9 IC50 ChEMBL
P27361 MAPK3 Homo sapiens Human PF00069 7.7 IC50 BindingDB
P49841 GSK3B Homo sapiens Human PF00069 7.6 IC50 ChEMBL;BindingDB
P06241 FYN Homo sapiens Human PF07714 PF00017 PF00018 7.2 Ki ChEMBL
O60563 CCNT1 Homo sapiens Human PF00134 PF21797 7.2 IC50 ChEMBL;BindingDB
O60583 CCNT2 Homo sapiens Human PF00134 PF21797 7.2 IC50 ChEMBL
P50750 CDK9 Homo sapiens Human PF00069 7.2 IC50 ChEMBL
O00311 CDC7 Homo sapiens Human PF00069 7.0 Ki ChEMBL
P07948 LYN Homo sapiens Human PF07714 PF00017 PF00018 6.9 Ki ChEMBL
P00519 ABL1 Homo sapiens Human PF08919 PF07714 PF00017 PF00018 6.8 Ki ChEMBL
Q8N4C6 NIN Homo sapiens Human 6.6 Ki BindingDB
O00444 PLK4 Homo sapiens Human PF00069 PF18190 PF18409 6.4 Ki ChEMBL
O95067 CCNB2 Homo sapiens Human PF02984 PF00134 6.4 IC50 ChEMBL
P06493 CDK1 Homo sapiens Human PF00069 6.4 IC50 ChEMBL;BindingDB
P14635 CCNB1 Homo sapiens Human PF02984 PF00134 6.4 IC50 ChEMBL
P17948 FLT1 Homo sapiens Human PF07679 PF00047 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.4 Ki ChEMBL
P35916 FLT4 Homo sapiens Human PF07679 PF13927 PF22971 PF07714 PF21339 PF17988 PF22854 6.4 Ki ChEMBL
P68400 CSNK2A1 Homo sapiens Human PF00069 6.4 Ki ChEMBL
Q8WWL7 CCNB3 Homo sapiens Human PF02984 PF00134 6.4 IC50 ChEMBL
P06239 LCK Homo sapiens Human PF07714 PF00017 PF00018 6.3 IC50 ChEMBL;BindingDB
O96017 CHEK2 Homo sapiens Human PF00498 PF00069 6.2 Ki ChEMBL
P27448 MARK3 Homo sapiens Human PF02149 PF00069 PF00627 6.2 Ki ChEMBL
Q13188 STK3 Homo sapiens Human PF11629 PF00069 6.2 Ki ChEMBL
P20248 CCNA2 Homo sapiens Human PF02984 PF00134 PF16500 6.2 IC50 ChEMBL
P24941 CDK2 Homo sapiens Human PF00069 6.2 IC50 ChEMBL;BindingDB
P78396 CCNA1 Homo sapiens Human PF02984 PF00134 PF16500 6.2 IC50 ChEMBL
Q00535 CDK5 Homo sapiens Human PF00069 6.1 IC50 ChEMBL
Q15078 CDK5R1 Homo sapiens Human PF03261 6.1 IC50 ChEMBL;BindingDB
P12931 SRC Homo sapiens Human PF07714 PF00017 PF00018 6.0 Ki ChEMBL
Q7KZI7 MARK2 Homo sapiens Human PF02149 PF00069 PF00627 6.0 Ki ChEMBL