Molecule Details
InChIKeyQQIQOMIKWUAMAA-UHFFFAOYSA-N
Compound NameIrak4-IN-13
Canonical SMILESCN1CCC(n2cc(Nc3nc(OC4(C)CC4)c4nc(-c5cncnc5)ccc4n3)cn2)CC1
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)7
Pfam Stratification Cross-Family
Avg pChEMBL7.78
SourceChEMBL
2D Structure
2D structure
Activity Profile
Target Activities (7)
Target Gene Organism Category Pfam pChEMBL Type Source
P51617 IRAK1 Homo sapiens Human PF00531 PF00069 8.7 IC50 ChEMBL
Q9NWZ3 IRAK4 Homo sapiens Human PF07714 8.4 IC50 ChEMBL
O00329 PIK3CD Homo sapiens Human PF00454 PF00792 PF02192 PF00794 PF00613 7.8 IC50 ChEMBL
P04629 NTRK1 Homo sapiens Human PF13855 PF16920 PF07714 PF18613 7.7 IC50 ChEMBL
Q16288 NTRK3 Homo sapiens Human PF07679 PF00047 PF13855 PF16920 PF01462 PF07714 7.4 IC50 ChEMBL
Q06187 BTK Homo sapiens Human PF00779 PF00169 PF07714 PF00017 PF00018 7.4 IC50 ChEMBL
Q16620 NTRK2 Homo sapiens Human PF07679 PF13855 PF16920 PF01462 PF07714 7.1 IC50 ChEMBL