Molecule Details
| InChIKey | QQHMKNYGKVVGCZ-UHFFFAOYSA-N |
|---|---|
| Canonical SMILES | N=C1CCCN1Cc1[nH]c(=O)[nH]c(=O)c1Cl |
| Clinical Status | Data-mined Candidate |
| Targets (Human+Pathogen) | 2 |
| Pfam Stratification | Homologous |
| Avg pChEMBL | 7.62 |
| Source | ChEMBL;BindingDB |
2D Structure
Activity Profile
DrugBank Annotations
| DrugBank ID | DB09343 |
|---|---|
| Drug Name | Tipiracil |
| CAS Number | 183204-74-2 |
| Groups | approved investigational |
| ATC Codes | nan |
| Description | Tipiracil is a thymidine phosphorylase inhibitor. It is used in combination with trifluridine, in a ratio of 1:0.5, to form TAS-102. The main function of Tipiracil in TAS-102 is to increase trifluridine bioavailability by inhibiting its catabolism.[A31255] TAS-102 is indicated for the treatment of m... |
Categories: MATE 1 Substrates MATE 1 Substrates with a Narrow Therapeutic Index MATE substrates Narrow Therapeutic Index Drugs OCT2 Substrates OCT2 Substrates with a Narrow Therapeutic Index Pyrimidines Pyrimidinones Thymidine Phosphorylase Inhibitor
Cross-references: BindingDB: 50531739 ChEBI: 90879 CHEMBL235668 ChemSpider: 13243748 Drugs Product Database (DPD): 22929 PubChem:6323266 PubChem:310265218 RxCUI: 1670304 Wikipedia: Tipiracil ZINC: ZINC000100032379