Molecule Details
InChIKeyQPYJXFZUIJOGNX-HSUXUTPPSA-N
Compound NameAfegostat
Canonical SMILESOC[C@H]1CNC[C@@H](O)[C@@H]1O
Clinical Status Data-mined Candidate
Targets (Human+Pathogen)3
Pfam Stratification Cross-Family
Avg pChEMBL7.13
SourceChEMBL;BindingDB
2D Structure
2D structure
Activity Profile
DrugBank Annotations
DrugBank ID DB04545
Drug NameAfegostat
CAS Number169105-89-9
Groups investigational
ATC Codes nan
Descriptionnan

Categories: Carbohydrates Glycoside Hydrolases, antagonists & inhibitors Imines Imino Sugars Piperidines
Cross-references: BindingDB: 50182801 CHEMBL206468 ChemSpider: 394649 PDB: IFM PubChem:447607 PubChem:46505453 Wikipedia: Afegostat ZINC: ZINC000003813668
Target Activities (3)
Target Gene Organism Category Pfam pChEMBL Type Source
Q9HCG7 GBA2 Homo sapiens Human PF04685 PF12215 7.7 IC50 ChEMBL;BindingDB
P04062 GBA1 Homo sapiens Human PF02055 PF17189 7.5 IC50 ChEMBL;BindingDB
P06737 PYGL Homo sapiens Human PF00343 6.2 IC50 ChEMBL;BindingDB
DrugBank Target Actions (4)
Target Gene Target Name Action Type
O85465 O85465 Endoglucanase 5A binder targets
Q08638 Q08638 Beta-glucosidase A binder targets
Q79G13 Q79G13 Glucanase binder targets
P04062 GBA1 Lysosomal acid glucosylceramidase inhibitor targets